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ChemicalBook >> CAS DataBase List >> PF-03814735

PF-03814735

PF-03814735 price.
  • $37 - $1126
  • Product name: PF-03814735
  • CAS: 942487-16-3
  • MF: C23H25F3N6O2
  • MW: 474.48
  • EINECS:-0
  • MDL Number:MFCD16659065
  • Synonyms:PF-03814735;N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide;Acetamide, N-[2-[(1S,4R)-6-[[4-(cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-;RYYNGWLOYLRZLK-RBUKOAKNSA-N;CS-240;PF-03814735 USP/EP/BP;Abecarnil Impurity 3;PF-03814735 PF03814735
25 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 50
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number2639AH
  • Product descriptionN-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide
  • Packaging50mg
  • Price$927
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4128
  • Product descriptionPF-03814735
  • Packaging5mg
  • Price$197
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4128
  • Product descriptionPF-03814735
  • Packaging10mg
  • Price$372
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4128
  • Product descriptionPF-03814735
  • Packaging50mg
  • Price$1126
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2023
  • Product descriptionPF03814735 98%
  • Packaging5mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15015
  • Product descriptionPF-03814735 ≥95%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15015
  • Product descriptionPF-03814735 ≥95%
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15015
  • Product descriptionPF-03814735 ≥95%
  • Packaging10mg
  • Price$213
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15015
  • Product descriptionPF-03814735 ≥95%
  • Packaging50mg
  • Price$793
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM141482
  • Product descriptionN-(2-((1S,4R)-6-((4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide 98%
  • Packaging50mg
  • Price$468
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0684
  • Product descriptionPF-03814735 99.82%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-0684
  • Product descriptionPF-03814735 99.82%
  • Packaging10mg
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0684
  • Product descriptionPF-03814735 99.82%
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000141
  • Product descriptionPF-03814735 98+%
  • Packaging5mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000141
  • Product descriptionPF-03814735 98+%
  • Packaging10mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000141
  • Product descriptionPF-03814735 98+%
  • Packaging50mg
  • Price$500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2639AH N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide 50mg $927 2021-12-16 Buy
ApexBio Technology A4128 PF-03814735 5mg $197 2021-12-16 Buy
ApexBio Technology A4128 PF-03814735 10mg $372 2021-12-16 Buy
ApexBio Technology A4128 PF-03814735 50mg $1126 2021-12-16 Buy
Axon Medchem Axon2023 PF03814735 98% 5mg $132 2021-12-16 Buy
Cayman Chemical 15015 PF-03814735 ≥95% 1mg $37 2024-03-01 Buy
Cayman Chemical 15015 PF-03814735 ≥95% 5mg $116 2024-03-01 Buy
Cayman Chemical 15015 PF-03814735 ≥95% 10mg $213 2024-03-01 Buy
Cayman Chemical 15015 PF-03814735 ≥95% 50mg $793 2024-03-01 Buy
Chemenu CM141482 N-(2-((1S,4R)-6-((4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide 98% 50mg $468 2021-12-16 Buy
ChemScene CS-0684 PF-03814735 99.82% 5mg $120 2021-12-16 Buy
ChemScene CS-0684 PF-03814735 99.82% 10mg $216 2021-12-16 Buy
ChemScene CS-0684 PF-03814735 99.82% 50mg $720 2021-12-16 Buy
Crysdot CD31000141 PF-03814735 98+% 5mg $88 2021-12-16 Buy
Crysdot CD31000141 PF-03814735 98+% 10mg $165 2021-12-16 Buy
Crysdot CD31000141 PF-03814735 98+% 50mg $500 2021-12-16 Buy

Properties

Melting point :181-183°C
Density :1.443
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :15.02±0.46(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.

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