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ChemicalBook >> CAS DataBase List >> AMG 900

AMG 900

AMG 900 price.
  • $35 - $2000
  • Product name: AMG 900
  • CAS: 945595-80-2
  • MF: C28H21N7OS
  • MW: 503.58
  • EINECS:-0
  • MDL Number:MFCD18633194
  • Synonyms:N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine AMG 900;AMG 900;N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine;N-(4-((3-(2-Aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1;AMG-900;AMG900;1-Phthalazinamine, N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-;AMG 900 USP/EP/BP
36 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 1mg
  • 2mg
  • 5mg
  • 2x5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberX7461
  • Product descriptionN-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
  • Packaging25mg
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA563424
  • Product descriptionAMG-900 98%
  • Packaging5mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA563424
  • Product descriptionAMG-900 98%
  • Packaging10mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA563424
  • Product descriptionAMG-900 98%
  • Packaging25mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA563424
  • Product descriptionAMG-900 98%
  • Packaging50mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA563424
  • Product descriptionAMG-900 98%
  • Packaging100mg
  • Price$217
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA563424
  • Product descriptionAMG-900 98%
  • Packaging250mg
  • Price$395
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000701
  • Product descriptionAMG-900 95.00%
  • Packaging5MG
  • Price$303.6
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4119
  • Product descriptionAMG-900
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4119
  • Product descriptionAMG-900
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4119
  • Product descriptionAMG-900
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4119
  • Product descriptionAMG-900
  • Packaging50mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4119
  • Product descriptionAMG-900
  • Packaging200mg
  • Price$1490
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1783
  • Product descriptionAMG900 98%
  • Packaging2x5mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1783
  • Product descriptionAMG900 98%
  • Packaging25mg
  • Price$423.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA43339
  • Product descriptionN-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
  • Packaging50mg
  • Price$1000
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7461 N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine 25mg $158 2021-12-16 Buy
Ambeed A563424 AMG-900 98% 5mg $35 2021-12-16 Buy
Ambeed A563424 AMG-900 98% 10mg $55 2021-12-16 Buy
Ambeed A563424 AMG-900 98% 25mg $98 2021-12-16 Buy
Ambeed A563424 AMG-900 98% 50mg $137 2021-12-16 Buy
Ambeed A563424 AMG-900 98% 100mg $217 2021-12-16 Buy
Ambeed A563424 AMG-900 98% 250mg $395 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000701 AMG-900 95.00% 5MG $303.6 2021-12-16 Buy
ApexBio Technology A4119 AMG-900 5mg $110 2021-12-16 Buy
ApexBio Technology A4119 AMG-900 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology A4119 AMG-900 10mg $190 2021-12-16 Buy
ApexBio Technology A4119 AMG-900 50mg $590 2021-12-16 Buy
ApexBio Technology A4119 AMG-900 200mg $1490 2021-12-16 Buy
Axon Medchem Axon1783 AMG900 98% 2x5mg $176 2021-12-16 Buy
Axon Medchem Axon1783 AMG900 98% 25mg $423.5 2021-12-16 Buy
Biosynth Carbosynth FA43339 N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine 50mg $1000 2021-12-16 Buy

Properties

Boiling point :778.7±70.0 °C(Predicted)
Density :1.380
storage temp. :2-8°C(protect from light)
solubility :≥25.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.79±0.30(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Their expression is elevated in a variety of human cancers. AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively. It is greater than 10-fold selective for Aurora kinases over p38α, TYK2, JNK2, Met, and Tie2 (IC50s = 53, 220, 520, 550, and 650 nM, respectively). At 2-3 nM, AMG 900 has been shown to inhibit the proliferation of 26 different tumor cell lines in vitro, including cell lines resistant to either the antimitotic agent paclitaxel or to other Aurora kinase inhibitors. Furthermore, AMG 900 is reported to be broadly active in multiple xenograft models, including three multidrug-resistant xenograft models, representing five tumor types.