NSC 663284
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- $25 - $1194
- Product name: NSC 663284
- CAS: 383907-43-5
- MF: C15H16ClN3O3
- MW: 321.76
- EINECS:
- MDL Number:MFCD08276924
- Synonyms:CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem;5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-;CDC25 Phosphatase Inhibitor II, NSC 663284;NSC 663284 (DA3003-1);NSC 663284 (DA3003-1), Cdc25 inhibitor
24 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number7775BA
- Product description6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione
- Packaging5mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number7775BA
- Product description6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ66520
- Product descriptionNSC 663284
- Packaging1mg
- Price$66.5
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ66520
- Product descriptionNSC 663284
- Packaging10mg
- Price$420
- Updated2023-01-06
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000020
- Product descriptionNSC 663284 95.00%
- Packaging1MG
- Price$425
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000020
- Product descriptionNSC 663284 95.00%
- Packaging5MG
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000020
- Product descriptionNSC 663284 95.00%
- Packaging25MG
- Price$730
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6881
- Product descriptionNSC 663284
- Packaging5mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13303
- Product descriptionNSC 663284 ≥98%
- Packaging1mg
- Price$25
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13303
- Product descriptionNSC 663284 ≥98%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13303
- Product descriptionNSC 663284 ≥98%
- Packaging10mg
- Price$150
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13303
- Product descriptionNSC 663284 ≥98%
- Packaging25mg
- Price$313
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-7519
- Product descriptionNSC 663284 99.87%
- Packaging2mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7519
- Product descriptionNSC 663284 99.87%
- Packaging5mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7519
- Product descriptionNSC 663284 99.87%
- Packaging10mg
- Price$192
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7519
- Product descriptionNSC 663284 99.87%
- Packaging25mg
- Price$396
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 7775BA | 6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione | 5mg | $218 | 2021-12-16 | Buy |
| AK Scientific | 7775BA | 6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione | 10mg | $286 | 2021-12-16 | Buy |
| Alfa Aesar | J66520 | NSC 663284 | 1mg | $66.5 | 2023-06-20 | Buy |
| Alfa Aesar | J66520 | NSC 663284 | 10mg | $420 | 2023-01-06 | Buy |
| American Custom Chemicals Corporation | INB0000020 | NSC 663284 95.00% | 1MG | $425 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000020 | NSC 663284 95.00% | 5MG | $490 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000020 | NSC 663284 95.00% | 25MG | $730 | 2021-12-16 | Buy |
| ApexBio Technology | B6881 | NSC 663284 | 5mg | $156 | 2021-12-16 | Buy |
| Cayman Chemical | 13303 | NSC 663284 ≥98% | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 13303 | NSC 663284 ≥98% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 13303 | NSC 663284 ≥98% | 10mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 13303 | NSC 663284 ≥98% | 25mg | $313 | 2024-03-01 | Buy |
| ChemScene | CS-7519 | NSC 663284 99.87% | 2mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-7519 | NSC 663284 99.87% | 5mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-7519 | NSC 663284 99.87% | 10mg | $192 | 2021-12-16 | Buy |
| ChemScene | CS-7519 | NSC 663284 99.87% | 25mg | $396 | 2021-12-16 | Buy |
Properties
Boiling point :478.8±45.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL
form :solid
pka :6.79±0.10(Predicted)
color :red
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL
form :solid
pka :6.79±0.10(Predicted)
color :red
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
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Description
Three genes encode dual specificity phosphatases that are Cdc25 homologs. The phosphatases, Cdc25A through C, are proto-oncogenes and are often over-expressed in cancers. NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). NSC 663284 poorly inhibits other phosphatases, including Vaccinia virus VH1-related (IC50 = 4.0 μM), PTP1B (no inhibition), and the mitogen-activated protein kinase phosphatases (MKP) MKP-1 or -3 (no inhibition). By inhibiting Cdc25 isoforms, NSC 663284 prevents the dephosphorylation and activation of Cdk1 and Cdk2, arrests cells at both G1 and G2/M phases, and prevents the proliferation of several human tumor cell lines.Related product price
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Suppliers and manufacturers
InvivoChem
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Aladdin Scientific
3B Pharmachem (Wuhan) International Co.,Ltd.
MedChemexpress LLC
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Sigma-Aldrich
Shanghai EFE Biological Technology Co., Ltd.
