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ChemicalBook >> CAS DataBase List >> LUFFARIELLOLIDE

LUFFARIELLOLIDE

LUFFARIELLOLIDE price.
  • $166 - $708
  • Product name: LUFFARIELLOLIDE
  • CAS: 111149-87-2
  • MF: C25H38O3
  • MW: 386.57
  • EINECS:
  • MDL Number:MFCD00211056
  • Synonyms:LUFFARIELLOLIDE;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-;Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha
5 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • TRC
  • Usbiological
Package
  • 500ug
  • 0.5mg
  • 1mg
  • ManufacturerAK Scientific
  • Product number1118CP
  • Product descriptionLuffariellolide
  • Packaging1mg
  • Price$262
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5100
  • Product descriptionLuffariellolide
  • Packaging1mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14902
  • Product descriptionLuffariellolide ≥98%
  • Packaging1mg
  • Price$186
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberL473753
  • Product descriptionLuffariellolide
  • Packaging0.5mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number453957
  • Product descriptionLuffariellolide
  • Packaging500ug
  • Price$708
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1118CP Luffariellolide 1mg $262 2021-12-16 Buy
ApexBio Technology C5100 Luffariellolide 1mg $166 2021-12-16 Buy
Cayman Chemical 14902 Luffariellolide ≥98% 1mg $186 2024-03-01 Buy
TRC L473753 Luffariellolide 0.5mg $360 2021-12-16 Buy
Usbiological 453957 Luffariellolide 500ug $708 2021-12-16 Buy

Properties

Boiling point :541.7±50.0 °C(Predicted)
Density :1.006±0.06 g/cm3(Predicted)
solubility :DMSO: soluble; Ethanol: soluble
pka :9.98±0.40(Predicted)
form :Pale yellow oil.
InChI :InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InChIKey :JPWPYTMXSXYUPG-QZPYEDBESA-N
SMILES :O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).

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