BIO
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- $32 - $1300
- Product name: BIO
- CAS: 667463-62-9
- MF: C16H10BrN3O2
- MW: 356.17
- EINECS:
- MDL Number:MFCD08705318
- Synonyms:2H-Indol-2-one, 6-broMo-3-[(3E)-1,3-dihydro-3-(hydroxyiMino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-;6BIO;6-bromoindirubin-3-oxime;GSK3 Inhibitor IX1;BIO(GSK-3 Inhibitor IX;BIO (SM04554);InSolution? GSK-3 Inhibitor IX ;(2E,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
32 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Alfa Aesar
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 5mg
- 10mM(in 1mL DMSO)
- 10mg
- 25mg
- 30mg
- 50mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M005
- Product description6BIO ≥98%(NMR)
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M050
- Product description6BIO ≥99%(NMR)
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2268AH
- Product description(3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one
- Packaging10mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2268AH
- Product description(3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67275
- Product description6-Bromoindirubin-3'-oxime, 97%
- Packaging10mg
- Price$163
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67275
- Product description6-Bromoindirubin-3'-oxime, 97%
- Packaging50mg
- Price$756
- Updated2024-03-01
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging10mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging10mM(in 1mL DMSO)
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging50mg
- Price$399
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1693
- Product descriptionBIO-GSK-3inhibitorIX|6-Bromoindirubin-3'-oxime 98%
- Packaging50mg
- Price$368.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBB162775
- Product descriptionBIO
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBB162775
- Product descriptionBIO
- Packaging50mg
- Price$437.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13123
- Product descriptionBIO ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13123
- Product descriptionBIO ≥98%
- Packaging5mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13123
- Product descriptionBIO ≥98%
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13123
- Product descriptionBIO ≥98%
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0056-M005 | 6BIO ≥98%(NMR) | 5mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M050 | 6BIO ≥99%(NMR) | 50mg | $480 | 2021-12-16 | Buy |
| AK Scientific | 2268AH | (3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one | 10mg | $218 | 2021-12-16 | Buy |
| AK Scientific | 2268AH | (3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one | 50mg | $640 | 2021-12-16 | Buy |
| Alfa Aesar | J67275 | 6-Bromoindirubin-3'-oxime, 97% | 10mg | $163 | 2024-03-01 | Buy |
| Alfa Aesar | J67275 | 6-Bromoindirubin-3'-oxime, 97% | 50mg | $756 | 2024-03-01 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 10mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 10mM(in 1mL DMSO) | $108 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 50mg | $399 | 2021-12-16 | Buy |
| Axon Medchem | Axon1693 | BIO-GSK-3inhibitorIX|6-Bromoindirubin-3'-oxime 98% | 50mg | $368.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BB162775 | BIO | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BB162775 | BIO | 50mg | $437.5 | 2021-12-16 | Buy |
| Cayman Chemical | 13123 | BIO ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 13123 | BIO ≥98% | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 13123 | BIO ≥98% | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 13123 | BIO ≥98% | 25mg | $381 | 2024-03-01 | Buy |
Properties
Melting point :300°C(lit.)
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC50 ≥10 μM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.More related product prices
Olaparib 2,6-PYRIDINEDIAMINE, N6-[2-[[4-(2,4-DICHLOROPHENYL)-5-(1H-IMIDAZOL-1-YL)-2-PYRIMIDINYL]AMINO]ETHYL]-3-NITRO- xav-939 BKM120 (NVP-BKM120, Buparlisib) Y27632 (hydrochloride) KU-55933 Zidovudine Indirubin ESTETROL Ethylamine CHOLESTEROL ESTERASE Nicardipine hydrochloride 182004-65-5 QUAZINONE EPA (-)-VaritriolRelated product price
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$28-2147.1 - 2,6-PYRIDINEDIAMINE, N6-[2-[[4-(2,4-DICHLOROPHENYL)-5-(1H-IMIDAZOL-1-YL)-2-PYRIMIDINYL]AMINO]ETHYL]-3-NITRO-
$81-3327 - xav-939
$7-2097.8
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