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ChemicalBook >> CAS DataBase List >> GSK J4 HCl

GSK J4 HCl

GSK J4 HCl price.
  • $110 - $1962
  • Product name: GSK J4 HCl
  • CAS: 1373423-53-0
  • MF: C24H27N5O2
  • MW: 417.5
  • EINECS:
  • MDL Number:MFCD22683852
  • Synonyms:GSK J4;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester;GSK J4 HCl;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1);Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate;Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)prop;Histone Lysine Demethylase Inhibitor VIII, GSK-J4
16 prices
Selected condition：
Brand
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10mg
  • 50
  • 5mg
  • 25mg
  • 50mg
  • 2x25mg
  • 100mg
  • ManufacturerApexBio Technology
  • Product numberA4190
  • Product descriptionGSKJ4HCl
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4190
  • Product descriptionGSKJ4HCl
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60290
  • Product descriptionGSK-J4 ≥98%
  • Packaging10mg
  • Price$288
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1933
  • Product descriptionGSKJ4 99%
  • Packaging2x25mg
  • Price$616
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1933
  • Product descriptionGSKJ4 99%
  • Packaging25mg
  • Price$401.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1933
  • Product descriptionGSKJ4 99%
  • Packaging5mg
  • Price$115.5
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3986
  • Product descriptionGSK-J4 99.64%
  • Packaging10mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3986
  • Product descriptionGSK-J4 99.64%
  • Packaging50mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11270115
  • Product descriptionGSK-J4 97%
  • Packaging50mg
  • Price$1962
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11270115
  • Product descriptionGSK-J4 97%
  • Packaging10mg
  • Price$654
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7654
  • Product descriptionGSKJ4HCl >95%
  • Packaging100mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0701
  • Product descriptionGSK-J4 ≥98% (HPLC)
  • Packaging25mg
  • Price$469
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number420205
  • Product descriptionHistone Lysine Demethylase Inhibitor VIII, GSK-J4
  • Packaging10mg
  • Price$245
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0701
  • Product descriptionGSK-J4 ≥98% (HPLC)
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number4594
  • Product descriptionGSKJ4 ≥99%(HPLC)
  • Packaging50
  • Price$876
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberG797555
  • Product descriptionGSKJ4
  • Packaging10mg
  • Price$165
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology A4190 GSKJ4HCl 10mg $110 2021-12-16 Buy
ApexBio Technology A4190 GSKJ4HCl 50mg $350 2021-12-16 Buy
Arctom CFN60290 GSK-J4 ≥98% 10mg $288 2021-12-16 Buy
Axon Medchem Axon1933 GSKJ4 99% 2x25mg $616 2021-12-16 Buy
Axon Medchem Axon1933 GSKJ4 99% 25mg $401.5 2021-12-16 Buy
Axon Medchem Axon1933 GSKJ4 99% 5mg $115.5 2021-12-16 Buy
ChemScene CS-3986 GSK-J4 99.64% 10mg $144 2021-12-16 Buy
ChemScene CS-3986 GSK-J4 99.64% 50mg $420 2021-12-16 Buy
Crysdot CD11270115 GSK-J4 97% 50mg $1962 2021-12-16 Buy
Crysdot CD11270115 GSK-J4 97% 10mg $654 2021-12-16 Buy
DC Chemicals DC7654 GSKJ4HCl >95% 100mg $550 2021-12-16 Buy
Sigma-Aldrich SML0701 GSK-J4 ≥98% (HPLC) 25mg $469 2024-03-01 Buy
Sigma-Aldrich 420205 Histone Lysine Demethylase Inhibitor VIII, GSK-J4 10mg $245 2024-03-01 Buy
Sigma-Aldrich SML0701 GSK-J4 ≥98% (HPLC) 5mg $117 2024-03-01 Buy
Tocris 4594 GSKJ4 ≥99%(HPLC) 50 $876 2021-12-16 Buy
TRC G797555 GSKJ4 10mg $165 2021-12-16 Buy

Properties

Boiling point :581.2±50.0 °C(Predicted)
Density :1.216±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :5.95±0.10(Predicted)
form :Tan semi-solid
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :WBKCKEHGXNWYMO-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393).1 GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.2

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