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ChemicalBook >> CAS DataBase List >> GSK-2126458

GSK-2126458

GSK-2126458 price.
  • $49 - $8373.75
  • Product name: GSK-2126458
  • CAS: 1086062-66-9
  • MF: C25H17F2N5O3S
  • MW: 505.5
  • EINECS:629-873-1
  • MDL Number:MFCD16038929
  • Synonyms:GSK2126458;GSK-2126458;GSK2126458; GSK-2126458;2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide;HYR-582;GSK212;2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide;OMipalisib
35 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 50
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • 2x25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1126-M001
  • Product descriptionGSK2126458 ≥95%
  • Packaging1mg
  • Price$157
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1126
  • Product descriptionGSK2126458
  • Packaging10mg
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0106597
  • Product description2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00%
  • Packaging10MG
  • Price$6641.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0106597
  • Product description2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00%
  • Packaging25MG
  • Price$8373.75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8556
  • Product descriptionGSK2126458
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8556
  • Product descriptionGSK2126458
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8556
  • Product descriptionGSK2126458
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8556
  • Product descriptionGSK2126458
  • Packaging50mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60257
  • Product descriptionOmipalisib(GSK2126458)
  • Packaging10mg
  • Price$378
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1596
  • Product descriptionGSK2126458-Omipalisib 99%
  • Packaging2x25mg
  • Price$506
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181012
  • Product descriptionOmipalisib (GSK-458) >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181012
  • Product descriptionOmipalisib (GSK-458) >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181012
  • Product descriptionOmipalisib (GSK-458) >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43337
  • Product descriptionGSK 2126458
  • Packaging10mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43337
  • Product descriptionGSK 2126458
  • Packaging50mg
  • Price$577.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17377
  • Product descriptionGSK2126458 ≥98%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1126-M001 GSK2126458 ≥95% 1mg $157 2021-12-16 Buy
AK Scientific SYN1126 GSK2126458 10mg $370 2021-12-16 Buy
American Custom Chemicals Corporation HCH0106597 2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00% 10MG $6641.25 2021-12-16 Buy
American Custom Chemicals Corporation HCH0106597 2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00% 25MG $8373.75 2021-12-16 Buy
ApexBio Technology A8556 GSK2126458 5mg $120 2021-12-16 Buy
ApexBio Technology A8556 GSK2126458 10mM(in 1mL DMSO) $130 2021-12-16 Buy
ApexBio Technology A8556 GSK2126458 10mg $150 2021-12-16 Buy
ApexBio Technology A8556 GSK2126458 50mg $420 2021-12-16 Buy
Arctom CFN60257 Omipalisib(GSK2126458) 10mg $378 2021-12-16 Buy
Axon Medchem Axon1596 GSK2126458-Omipalisib 99% 2x25mg $506 2021-12-16 Buy
Biorbyt Ltd orb181012 Omipalisib (GSK-458) >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb181012 Omipalisib (GSK-458) >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb181012 Omipalisib (GSK-458) >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FD43337 GSK 2126458 10mg $165 2021-12-16 Buy
Biosynth Carbosynth FD43337 GSK 2126458 50mg $577.5 2021-12-16 Buy
Cayman Chemical 17377 GSK2126458 ≥98% 1mg $49 2024-03-01 Buy

Properties

Melting point :187-189℃
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.

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