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ChemicalBook >> CAS DataBase List >> EST

EST

EST price.
  • $28 - $2484
  • Product name: EST
  • CAS: 88321-09-9
  • MF: C17H30N2O5
  • MW: 342.43
  • EINECS:
  • MDL Number:MFCD00132883
  • Synonyms:COT (30-397), active, GST tagged human;2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-;E 64d (Aloxistatin);(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]-butyl]amino]carbonyl]-2-oxiranec;L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER;L-TRANS-EPOXYSUCCINYL(OET)-LEU-3-METHYLBUTYLAMIDE;LOXASTATIN;LOXISTATIN
44 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Ark Pharm
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
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  • Usbiological
Package
  • 10μg
  • 250μg
  • 1unit
  • 2.5mg
  • 1
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3737-M001
  • Product descriptionAloxistatin[E-64d] ≥95%(HPLC)
  • Packaging1mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3737-M025
  • Product descriptionAloxistatin[E-64d] ≥95%(HPLC)
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX6849
  • Product description(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutaneethylester
  • Packaging250mg
  • Price$818
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ65822
  • Product descriptionLoxistatin
  • Packaging1mg
  • Price$77.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ65822
  • Product descriptionLoxistatin
  • Packaging5mg
  • Price$308
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000148
  • Product descriptionE-64-D 95.00%
  • Packaging1MG
  • Price$444
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000148
  • Product descriptionE-64-D 95.00%
  • Packaging5MG
  • Price$611
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1903
  • Product descriptionE64d
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging1mg
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging10mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging25mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging100mg
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging250mg
  • Price$428
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS458944
  • Product descriptionAloxistatin 98%
  • Packaging1g
  • Price$1069
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberAK176021
  • Product descriptionAloxistatin 98%
  • Packaging100mg
  • Price$298
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3737-M001 Aloxistatin[E-64d] ≥95%(HPLC) 1mg $30 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3737-M025 Aloxistatin[E-64d] ≥95%(HPLC) 25mg $240 2021-12-16 Buy
AK Scientific X6849 (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutaneethylester 250mg $818 2021-12-16 Buy
Alfa Aesar J65822 Loxistatin 1mg $77.2 2021-12-16 Buy
Alfa Aesar J65822 Loxistatin 5mg $308 2021-12-16 Buy
American Custom Chemicals Corporation INB0000148 E-64-D 95.00% 1MG $444 2021-12-16 Buy
American Custom Chemicals Corporation INB0000148 E-64-D 95.00% 5MG $611 2021-12-16 Buy
ApexBio Technology A1903 E64d 1unit $28 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 1mg $41 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 5mg $80 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 10mg $111 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 25mg $144 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 100mg $289 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 250mg $428 2021-12-16 Buy
Arctom AS458944 Aloxistatin 98% 1g $1069 2021-12-16 Buy
Ark Pharm AK176021 Aloxistatin 98% 100mg $298 2021-12-16 Buy

Properties

Melting point :126.2°C
Boiling point :477.88°C (rough estimate)
Density :1.0657 (rough estimate)
refractive index :1.5800 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO, DMF or ethanol
pka :13.32±0.40(Predicted)
form :White solid
color :Fine needles from EtOH
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases. E-64d inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. By disrupting protease activity, E-64d, at concentrations between 20-200 μM, has been shown to arrest human epidermoid carcinoma A431 cells at mitotic metaphase. It also inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM.

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