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ChemicalBook >> CAS DataBase List >> Dofetilide

Dofetilide

Dofetilide price.
  • $7 - $1190
  • Product name: Dofetilide
  • CAS: 115256-11-6
  • MF: C19H27N3O5S2
  • MW: 441.56
  • EINECS:638-817-5
  • MDL Number:MFCD00869707
  • Synonyms:Tikosyn;beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl) phenyl);Tikosym;Methyl[2-[4-(methylsulfonylamino)phenoxy]ethyl][4-(methylsulfonylamino)phenethyl]amine;N-[4-[2-[N-Methyl-2-(4-methylsulfonylaminophenoxy)ethylamino]ethyl]phenyl]methanesulfonamide;U-68798;N-[4-[2-[2-[4-(methanesulfonamido)phenyl]ethyl-methylamino]ethoxy]phenyl]methanesulfonamide
38 prices
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  • AHH
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
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Package
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  • 5mg
  • 10mg
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  • 5
  • 50mg
  • 0.1g
  • 100mg
  • 200mg
  • 500mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 250mg
  • 2g
  • ManufacturerAHH
  • Product numberAPI-1606
  • Product descriptionDofetilide 98%
  • Packaging0.1g
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberI881
  • Product descriptionDofetilide
  • Packaging5mg
  • Price$39
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging10mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging25mg
  • Price$16
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging50mg
  • Price$23
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging100mg
  • Price$34
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging250mg
  • Price$58
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA253881
  • Product descriptionN-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+%
  • Packaging1g
  • Price$147
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8417
  • Product descriptionDofetilide
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8417
  • Product descriptionDofetilide
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2174
  • Product descriptionDofetilide
  • Packaging10mg
  • Price$49
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2174
  • Product descriptionDofetilide
  • Packaging25mg
  • Price$89
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2174
  • Product descriptionDofetilide
  • Packaging100mg
  • Price$249
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2174
  • Product descriptionDofetilide
  • Packaging250mg
  • Price$449
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2174
  • Product descriptionDofetilide
  • Packaging1g
  • Price$1190
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1606 Dofetilide 98% 0.1g $370 2021-12-16 Buy
AK Scientific I881 Dofetilide 5mg $39 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 5mg $7 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 10mg $10 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 25mg $16 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 50mg $23 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 100mg $34 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 250mg $58 2021-12-16 Buy
Ambeed A253881 N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide 98+% 1g $147 2021-12-16 Buy
ApexBio Technology A8417 Dofetilide 10mg $60 2021-12-16 Buy
ApexBio Technology A8417 Dofetilide 10mM(in 1mL DMSO) $60 2021-12-16 Buy
AvaChem 2174 Dofetilide 10mg $49 2021-12-16 Buy
AvaChem 2174 Dofetilide 25mg $89 2021-12-16 Buy
AvaChem 2174 Dofetilide 100mg $249 2021-12-16 Buy
AvaChem 2174 Dofetilide 250mg $449 2021-12-16 Buy
AvaChem 2174 Dofetilide 1g $1190 2021-12-16 Buy

Properties

Melting point :147-1490C
Boiling point :614.1±65.0 °C(Predicted)
Density :1.344±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.0, 9.0, 9.6(at 25℃)
form :powder
color :white to off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :IXTMWRCNAAVVAI-UHFFFAOYSA-N
CAS DataBase Reference :115256-11-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM dofetilide demonstrates pro-arrhythmic activity, inducing early after depolarizations (prolonged repolarization) in cell models and Torsade de Pointes in animal models. Given this adverse side effect, dofetilide has been cautiously used in the treatment of atrial fibrillation, the conversion of flutter to sinus rhythm, and in the maintenance of sinus rhythm after conversion.

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