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ChemicalBook >> CAS DataBase List >> Cefotaxime

Cefotaxime

Cefotaxime price.
  • $50 - $1666
  • Product name: Cefotaxime
  • CAS: 63527-52-6
  • MF: C16H17N5O7S2
  • MW: 455.47
  • EINECS:264-299-1
  • MDL Number:MFCD00864971
  • Synonyms:Cefotaxime;Cefotaxima acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-;Cefabol;Cephotaxime;(((2-amino- 4-thiazolyl)methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z) 3-[(Acetyloxy)methyl]-7-[[(2-amino-4-thiazoly)(methoxyimino)acethyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid(sodium salt);(6R)-3-(Acetoxymethyl)-7α-[[(2-amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
11 prices
Selected condition：
Brand
  • AHH
  • AK Scientific
  • ChemScene
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
Package
  • y0000420
  • 25mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 2.5g
  • 5g
  • ManufacturerAHH
  • Product numberMT-49079
  • Product descriptionCefotaxime 98%
  • Packaging5g
  • Price$310
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90010
  • Product descriptionCefotaxime
  • Packaging1g
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF941
  • Product descriptionCefotaxime
  • Packaging25mg
  • Price$98.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90010
  • Product descriptionCefotaxime
  • Packaging5g
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0013515
  • Product descriptionCefotaxime 99.55%
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0013515
  • Product descriptionCefotaxime 99.55%
  • Packaging250mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0013515
  • Product descriptionCefotaxime 99.55%
  • Packaging500mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number145093
  • Product description(6R,7R)-3-(Acetoxymethyl)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 95%
  • Packaging1g
  • Price$1110
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number145093
  • Product description(6R,7R)-3-(Acetoxymethyl)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 95%
  • Packaging5g
  • Price$1666
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0000420
  • Product descriptionCefotaxime acid European Pharmacopoeia (EP) Reference Standard
  • Packagingy0000420
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberC242958
  • Product descriptionCefotaxime
  • Packaging2.5g
  • Price$225
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-49079 Cefotaxime 98% 5g $310 2021-12-16 Buy
AK Scientific J90010 Cefotaxime 1g $60 2021-12-16 Buy
AK Scientific F941 Cefotaxime 25mg $98.6 2021-12-16 Buy
AK Scientific J90010 Cefotaxime 5g $150 2021-12-16 Buy
ChemScene CS-0013515 Cefotaxime 99.55% 100mg $50 2021-12-16 Buy
ChemScene CS-0013515 Cefotaxime 99.55% 250mg $100 2021-12-16 Buy
ChemScene CS-0013515 Cefotaxime 99.55% 500mg $135 2021-12-16 Buy
Matrix Scientific 145093 (6R,7R)-3-(Acetoxymethyl)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 95% 1g $1110 2021-12-16 Buy
Matrix Scientific 145093 (6R,7R)-3-(Acetoxymethyl)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 95% 5g $1666 2021-12-16 Buy
Sigma-Aldrich Y0000420 Cefotaxime acid European Pharmacopoeia (EP) Reference Standard y0000420 $220 2024-03-01 Buy
TRC C242958 Cefotaxime 2.5g $225 2021-12-16 Buy

Properties

Melting point :>158°C (dec.)
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :pKa 2.1 (H2O t=20.0 I<0.005 ) (Uncertain);3.4(H2O t=20.0 I<0.005 ) (Uncertain);10.9(H2O t=20.0 I<0.005 ) (Uncertain)
form :Solid
color :White to Off-White
Stability :Hygroscopic
LogP :1.2
CAS DataBase Reference :63527-52-6(CAS DataBase Reference)
EPA Substance Registry System :5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)- (63527-52-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Description

Like other third-generation cephalosporins, it has excellent anti-Gram-negative activity and is useful institutionally. It has a metabolically vulnerable acetoxy group attached to C-3 and loses approximately 90% of its activity when this is hydrolyzed. This metabolic feature also complicates the pharmacokinetic data, because both active forms are present and have different properties. Cefotaxime should be protected from heat and light and may color slightly without significant loss of potency. Like other third-generation cephalosporins, cefotaxime has less activity against staphylococci but has greater activity against Gram-negative organisms.

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