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ChemicalBook >> CAS DataBase List >> (+)-Bicuculline

(+)-Bicuculline

(+)-Bicuculline price.
  • $44 - $4500
  • Product name: (+)-Bicuculline
  • CAS: 485-49-4
  • MF: C20H17NO6
  • MW: 367.35
  • EINECS:207-619-7
  • MDL Number:MFCD00005006
  • Synonyms:5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( ;bicucullin ;Bucuculline;d-Bicuculline/(+)-Bicuculline;D-alkali than buttoned Spirit;Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-;6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one;furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo
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  • Adipogen Life Sciences
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  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-B0239-M500
  • Product description(+)-Bicuculline ≥99%(HPLC)
  • Packaging500mg
  • Price$215
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberV0271
  • Product description(+)-Bicuculline
  • Packaging25mg
  • Price$70
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberV0271
  • Product description(+)-Bicuculline
  • Packaging100mg
  • Price$191
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberN1592
  • Product description(+)-Bicuculline
  • Packaging100mg
  • Price$100
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberN1592
  • Product description(+)-Bicuculline
  • Packaging10mM(in 1mL DMSO)
  • Price$100
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberN1592
  • Product description(+)-Bicuculline
  • Packaging250mg
  • Price$200
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberSY060100
  • Product description(+)-Bicuculline ≥98%
  • Packaging10mg
  • Price$49.09
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS012839
  • Product description(R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one ≥98%
  • Packaging100mg
  • Price$52
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN99748
  • Product description(+)-Bicuculline ≥98%
  • Packaging20mg
  • Price$80
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS012839
  • Product description(R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one ≥98%
  • Packaging250mg
  • Price$124
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1973
  • Product description(+)-Bicuculline
  • Packaging10mg
  • Price$49
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1973
  • Product description(+)-Bicuculline
  • Packaging100mg
  • Price$119
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1973
  • Product description(+)-Bicuculline
  • Packaging1g
  • Price$480
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberBB164251
  • Product description(+)-Bicuculline
  • Packaging25mg
  • Price$47
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberBB164251
  • Product description(+)-Bicuculline
  • Packaging100mg
  • Price$97
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFB18590
  • Product description(+)-Bicuculline
  • Packaging500mg
  • Price$300
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-B0239-M500 (+)-Bicuculline ≥99%(HPLC) 500mg $215 2021-12-16 Buy
AK Scientific V0271 (+)-Bicuculline 25mg $70 2021-12-16 Buy
AK Scientific V0271 (+)-Bicuculline 100mg $191 2021-12-16 Buy
ApexBio Technology N1592 (+)-Bicuculline 100mg $100 2021-12-16 Buy
ApexBio Technology N1592 (+)-Bicuculline 10mM(in 1mL DMSO) $100 2021-12-16 Buy
ApexBio Technology N1592 (+)-Bicuculline 250mg $200 2021-12-16 Buy
Arctom SY060100 (+)-Bicuculline ≥98% 10mg $49.09 2021-12-16 Buy
Arctom AS012839 (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one ≥98% 100mg $52 2021-12-16 Buy
Arctom CFN99748 (+)-Bicuculline ≥98% 20mg $80 2021-12-16 Buy
Arctom AS012839 (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one ≥98% 250mg $124 2021-12-16 Buy
AvaChem 1973 (+)-Bicuculline 10mg $49 2021-12-16 Buy
AvaChem 1973 (+)-Bicuculline 100mg $119 2021-12-16 Buy
AvaChem 1973 (+)-Bicuculline 1g $480 2021-12-16 Buy
Biosynth Carbosynth BB164251 (+)-Bicuculline 25mg $47 2021-12-16 Buy
Biosynth Carbosynth BB164251 (+)-Bicuculline 100mg $97 2021-12-16 Buy
Biosynth Carbosynth FB18590 (+)-Bicuculline 500mg $300 2021-12-16 Buy

Properties

Melting point :193-197 °C
alpha :D25 +130.5° (CHCl3)
Boiling point :497.92°C (rough estimate)
Density :1.3694 (rough estimate)
refractive index :1.5600 (estimate)
storage temp. :2-8°C
solubility :Benzene, Chloroform, DMSO, Ethyl Acetate
form :Off-white to yellow powder.
pka :4.84(at 25℃)
color :Pale Yellow
optical activity :[α]20/D +126±6°, c = 1% in chloroform
λmax :325nm(lit.)
Merck :14,1203
BRN :98786
InChIKey :IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference :485-49-4(CAS DataBase Reference)
EPA Substance Registry System :Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors. At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons. Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM. By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.

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