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ChemicalBook >> CAS DataBase List >> Axitinib-13C-d3

Axitinib-13C-d3

Axitinib-13C-d3 price.
  • $605 - $1151
  • Product name: Axitinib-13C-d3
  • CAS: 1261432-00-1
  • MF:
  • MW: 0
  • EINECS:
  • MDL Number:MFCD32858131
  • Synonyms:Axitinib-13C-d3;[13C,2H3]-Axitinib;(E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
2 prices
Selected condition：
Brand
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • ManufacturerCayman Chemical
  • Product number26676
  • Product descriptionAxitinib-13C-d3
  • Packaging1mg
  • Price$1151
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26676
  • Product descriptionAxitinib-13C-d3
  • Packaging500μg
  • Price$605
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 26676 Axitinib-13C-d3 1mg $1151 2024-03-01 Buy
Cayman Chemical 26676 Axitinib-13C-d3 500μg $605 2024-03-01 Buy

Properties

storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

Axitinib-13C-d3 is intended for use as an internal standard for the quantification of axitinib by GC- or LC-MS. Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively). It also inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbilical vein endothelial cells (HUVECs). Axitinib (1-100 mg/kg) reduces microvessel density, a marker of angiogenesis, and tumor growth in MV522 colon carcinoma, A375 melanoma, SN12C-GFP renal carcinoma, and U87 glioma mouse xenograft models in a dose-dependent manner. Formulations containing axitinib have been used in the treatment of renal cell carcinoma.