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ChemicalBook >> CAS DataBase List >> Avanafil

Avanafil

Avanafil price.
  • $5 - $789
  • Product name: Avanafil
  • CAS: 330784-47-9
  • MF: C23H26ClN7O3
  • MW: 483.95
  • EINECS:-0
  • MDL Number:MFCD11977961
  • Synonyms:4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;avanfil;(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl;avanafil:4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide: (s)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylami;(S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide;(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
34 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • Ambeed
  • ApexBio Technology
  • Apolloscientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
Package
  • 10mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 5mg
  • 25mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • 10g
  • 25g
  • ManufacturerAK Scientific
  • Product numberJ11129
  • Product descriptionAvanafil
  • Packaging5mg
  • Price$19.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11129
  • Product descriptionAvanafil
  • Packaging25mg
  • Price$79.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberZ5510
  • Product descriptionAvanafil
  • Packaging500mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberZ5510
  • Product descriptionAvanafil
  • Packaging1g
  • Price$163
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number330784479
  • Product descriptionAvanafil
  • Packaging1g
  • Price$168.21
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number330784479
  • Product descriptionAvanafil
  • Packaging5g
  • Price$454.94
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging10mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging50mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging250mg
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging1g
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging5g
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA803364
  • Product description(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+%
  • Packaging25g
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4334
  • Product descriptionAvanafil
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4334
  • Product descriptionAvanafil
  • Packaging50mg
  • Price$61
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR302290
  • Product description4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
  • Packaging1g
  • Price$285
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J11129 Avanafil 5mg $19.8 2021-12-16 Buy
AK Scientific J11129 Avanafil 25mg $79.2 2021-12-16 Buy
AK Scientific Z5510 Avanafil 500mg $94 2021-12-16 Buy
AK Scientific Z5510 Avanafil 1g $163 2021-12-16 Buy
Alichem 330784479 Avanafil 1g $168.21 2021-12-16 Buy
Alichem 330784479 Avanafil 5g $454.94 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 10mg $5 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 50mg $9 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 100mg $16 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 250mg $24 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 1g $45 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 5g $149 2021-12-16 Buy
Ambeed A803364 (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 98+% 25g $500 2021-12-16 Buy
ApexBio Technology A4334 Avanafil 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A4334 Avanafil 50mg $61 2021-12-16 Buy
Apolloscientific OR302290 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide 1g $285 2021-12-16 Buy

Properties

Melting point :150-152°C
Density :1.372
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
form :Solid
pka :11.84±0.46(Predicted)
color :White to Off-White
InChIKey :WEAJZXNPAWBCOA-INIZCTEOSA-N
SMILES :C1(N2CCC[C@H]2CO)=NC=C(C(NCC2=NC=CC=N2)=O)C(NCC2=CC=C(OC)C(Cl)=C2)=N1
CAS DataBase Reference :330784-47-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.

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