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ChemicalBook >> CAS DataBase List >> AR-A014418

AR-A014418

AR-A014418 price.
  • $28 - $1253
  • Product name: AR-A014418
  • CAS: 487021-52-3
  • MF: C12H12N4O4S
  • MW: 308.31
  • EINECS:
  • MDL Number:MFCD08277040
  • Synonyms:N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea AR 0133418;AR 0133418;GSK 3B Inhibitor VIII;AR 014418;GSK 3β inhibitor;1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea;AR-A014418/ARA014418;SN 4521
32 prices
Selected condition：
Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1unit
  • 5mg
  • 10mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 25mg
  • 2x25mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number2224AH
  • Product description1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
  • Packaging250mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2224AH
  • Product description1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
  • Packaging1g
  • Price$413
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2224AH
  • Product description1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
  • Packaging5g
  • Price$1129
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64554
  • Product descriptionGSK-3beta Inhibitor VIII
  • Packaging10mg
  • Price$187
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA174426
  • Product descriptionAR-A014418 98+%
  • Packaging5mg
  • Price$51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174426
  • Product descriptionAR-A014418 98+%
  • Packaging10mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174426
  • Product descriptionAR-A014418 98+%
  • Packaging25mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174426
  • Product descriptionAR-A014418 98+%
  • Packaging50mg
  • Price$167
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174426
  • Product descriptionAR-A014418 98+%
  • Packaging100mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174426
  • Product descriptionAR-A014418 98+%
  • Packaging250mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3184
  • Product descriptionAR-A014418
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3184
  • Product descriptionAR-A014418
  • Packaging10mM(in 1mL DMSO)
  • Price$64
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3184
  • Product descriptionAR-A014418
  • Packaging10mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3184
  • Product descriptionAR-A014418
  • Packaging50mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2167
  • Product descriptionAR-A014418 99%
  • Packaging2x25mg
  • Price$462
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA17968
  • Product descriptionAR-AO 14418
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2224AH 1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea 250mg $205 2021-12-16 Buy
AK Scientific 2224AH 1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea 1g $413 2021-12-16 Buy
AK Scientific 2224AH 1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea 5g $1129 2021-12-16 Buy
Alfa Aesar J64554 GSK-3beta Inhibitor VIII 10mg $187 2023-06-20 Buy
Ambeed A174426 AR-A014418 98+% 5mg $51 2021-12-16 Buy
Ambeed A174426 AR-A014418 98+% 10mg $76 2021-12-16 Buy
Ambeed A174426 AR-A014418 98+% 25mg $129 2021-12-16 Buy
Ambeed A174426 AR-A014418 98+% 50mg $167 2021-12-16 Buy
Ambeed A174426 AR-A014418 98+% 100mg $220 2021-12-16 Buy
Ambeed A174426 AR-A014418 98+% 250mg $330 2021-12-16 Buy
ApexBio Technology A3184 AR-A014418 1unit $28 2021-12-16 Buy
ApexBio Technology A3184 AR-A014418 10mM(in 1mL DMSO) $64 2021-12-16 Buy
ApexBio Technology A3184 AR-A014418 10mg $68 2021-12-16 Buy
ApexBio Technology A3184 AR-A014418 50mg $189 2021-12-16 Buy
Axon Medchem Axon2167 AR-A014418 99% 2x25mg $462 2021-12-16 Buy
Biosynth Carbosynth FA17968 AR-AO 14418 10mg $85 2021-12-16 Buy

Properties

Melting point :208-210?C (dec.)
Density :1.464±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL, clear, light yellow
form :Yellow solid
pka :5.80±0.70(Predicted)
color :off-white to tan
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

GSK3β Inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM). It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Kis = > 100 μM). GSK3β Inhibitor VIII demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death.

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