A-674563
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- $49 - $5541
- Product name: A-674563
- CAS: 552325-73-2
- MF: C22H22N4O
- MW: 358.44
- EINECS:
- MDL Number:MFCD11840461
- Synonyms:A-674563;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine;A-674563 /A674563;(2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563;A-674563 (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563 /A674563;A-674563;A 674563; A674563;(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
32 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Usbiological
Package
- 500μg
- 500ug
- 1mg
- 2MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- 5g
- 250mg
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3680-M005
- Product descriptionA-674563(freebase) ≥98%(HPLC)
- Packaging5mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1110-M001
- Product descriptionA-674563hydrochloride ≥95%
- Packaging1mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1110
- Product descriptionA-674563HCl
- Packaging10mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001241
- Product descriptionA-674563 95.00%
- Packaging2MG
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001241
- Product descriptionA-674563 95.00%
- Packaging5MG
- Price$498.93
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8616
- Product descriptionA-674563
- Packaging5mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8616
- Product descriptionA-674563
- Packaging10mM(in 1mL DMSO)
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8616
- Product descriptionA-674563
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8616
- Product descriptionA-674563
- Packaging50mg
- Price$630
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8616
- Product descriptionA-674563
- Packaging100mg
- Price$980
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60355
- Product descriptionA-674563
- Packaging5mg
- Price$338
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18715
- Product descriptionA-674563 ≥95%
- Packaging500μg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18715
- Product descriptionA-674563 ≥95%
- Packaging1mg
- Price$92
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18715
- Product descriptionA-674563 ≥95%
- Packaging5mg
- Price$333
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18715
- Product descriptionA-674563 ≥95%
- Packaging10mg
- Price$570
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM150660
- Product description(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine 98%
- Packaging100mg
- Price$982
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3680-M005 | A-674563(freebase) ≥98%(HPLC) | 5mg | $145 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1110-M001 | A-674563hydrochloride ≥95% | 1mg | $189 | 2021-12-16 | Buy |
| AK Scientific | SYN1110 | A-674563HCl | 10mg | $470 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001241 | A-674563 95.00% | 2MG | $300 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001241 | A-674563 95.00% | 5MG | $498.93 | 2021-12-16 | Buy |
| ApexBio Technology | A8616 | A-674563 | 5mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | A8616 | A-674563 | 10mM(in 1mL DMSO) | $154 | 2021-12-16 | Buy |
| ApexBio Technology | A8616 | A-674563 | 10mg | $210 | 2021-12-16 | Buy |
| ApexBio Technology | A8616 | A-674563 | 50mg | $630 | 2021-12-16 | Buy |
| ApexBio Technology | A8616 | A-674563 | 100mg | $980 | 2021-12-16 | Buy |
| Arctom | CFN60355 | A-674563 | 5mg | $338 | 2021-12-16 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 1mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 5mg | $333 | 2024-03-01 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 10mg | $570 | 2024-03-01 | Buy |
| Chemenu | CM150660 | (S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine 98% | 100mg | $982 | 2021-12-16 | Buy |
Properties
Boiling point :624.4±55.0 °C(Predicted)
Density :1.229
storage temp. :Store at -20°C
solubility :insoluble in EtOH; ≥23.8 mg/mL in H2O; ≥4.9 mg/mL in DMSO
form :solid
pka :13.43±0.40(Predicted)
color :White to yellow
Density :1.229
storage temp. :Store at -20°C
solubility :insoluble in EtOH; ≥23.8 mg/mL in H2O; ≥4.9 mg/mL in DMSO
form :solid
pka :13.43±0.40(Predicted)
color :White to yellow
Safety Information
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Description
Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki = 11 nM for Akt1). It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families. A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4 μM. In vivo, 40 mg/kg/day A-674563 in combination with 15 mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model.More related product prices
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