N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
![N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide price.](/CAS/20150408/GIF/916141-36-1.gif)
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- $32 - $1949.9
- Product name: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
- CAS: 916141-36-1
- MF: C27H26N4O2S
- MW: 470.59
- EINECS:
- MDL Number:MFCD18086894
- Synonyms:(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide;TCS-102;(2S)- 2-Pyrrolidinecarboxamide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl];2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)-;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide TCS1102;TCS 1102 N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;TCS 1102
20 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 10mg
- 50
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAK Scientific
- Product number4089AH
- Product description(2S)-1-[2-(1-Methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4089AH
- Product description(2S)-1-[2-(1-Methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
- Packaging5mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4089AH
- Product description(2S)-1-[2-(1-Methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1044
- Product descriptionTCS1102
- Packaging50mg
- Price$696
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181332
- Product descriptionTCS 1102 >98%
- Packaging100mg
- Price$654.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181332
- Product descriptionTCS 1102 >98%
- Packaging250mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181332
- Product descriptionTCS 1102 >98%
- Packaging1000mg
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18495
- Product descriptionTCS 1102 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18495
- Product descriptionTCS 1102 ≥98%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18495
- Product descriptionTCS 1102 ≥98%
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18495
- Product descriptionTCS1102 ≥98%
- Packaging25mg
- Price$305
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1923
- Product descriptionTCS1102 99.89%
- Packaging10mg
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1923
- Product descriptionTCS1102 99.89%
- Packaging50mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000272
- Product descriptionTCS1102 98+%
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000272
- Product descriptionTCS1102 98+%
- Packaging50mg
- Price$309
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7513
- Product descriptionTCS1102 >98%
- Packaging100mg
- Price$325
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4089AH | (2S)-1-[2-(1-Methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | 4089AH | (2S)-1-[2-(1-Methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide | 5mg | $226 | 2021-12-16 | Buy |
| AK Scientific | 4089AH | (2S)-1-[2-(1-Methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide | 10mg | $286 | 2021-12-16 | Buy |
| ApexBio Technology | B1044 | TCS1102 | 50mg | $696 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181332 | TCS 1102 >98% | 100mg | $654.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181332 | TCS 1102 >98% | 250mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181332 | TCS 1102 >98% | 1000mg | $1949.9 | 2021-12-16 | Buy |
| Cayman Chemical | 18495 | TCS 1102 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18495 | TCS 1102 ≥98% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 18495 | TCS 1102 ≥98% | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 18495 | TCS1102 ≥98% | 25mg | $305 | 2024-03-01 | Buy |
| ChemScene | CS-1923 | TCS1102 99.89% | 10mg | $102 | 2021-12-16 | Buy |
| ChemScene | CS-1923 | TCS1102 99.89% | 50mg | $360 | 2021-12-16 | Buy |
| Crysdot | CD31000272 | TCS1102 98+% | 10mg | $70 | 2021-12-16 | Buy |
| Crysdot | CD31000272 | TCS1102 98+% | 50mg | $309 | 2021-12-16 | Buy |
| DC Chemicals | DC7513 | TCS1102 >98% | 100mg | $325 | 2021-12-16 | Buy |
Properties
storage temp. :Sealed in dry,2-8°C
solubility :DMF: 25 mg/ml; DMF:PBS (pH 7) (1:10): 0.09 mg/ml; DMSO: 14 mg/ml; Ethanol: 10 mg/ml
form :Powder
color :White to off-white
solubility :DMF: 25 mg/ml; DMF:PBS (pH 7) (1:10): 0.09 mg/ml; DMSO: 14 mg/ml; Ethanol: 10 mg/ml
form :Powder
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally. Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse. Systemic injection of TCS 1102 (10 mg/kg i.p.) in rats decreases fear and anxiety in response to acute episodes of stress.Related product price
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