4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
![4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione price.](/CAS/GIF/865854-05-3.gif)
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- $33 - $1286
- Product name: 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
- CAS: 865854-05-3
- MF: C19H14N2O2S
- MW: 334.39
- EINECS:640-411-8
- MDL Number:MFCD18633296
- Synonyms:4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;Tideglusib(NP-031112);TIDEGLUSIB;NP-12;NP031112;NP 031112;NP-031112;1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-;Destructible;Tideglusib (NP031112, NP-12)
24 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 5MG
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX5395
- Product description4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
- Packaging1g
- Price$1286
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014171
- Product descriptionTIDEGLUSIB 95.00%
- Packaging5MG
- Price$141.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1539
- Product descriptionTideglusib
- Packaging200mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60383
- Product descriptionTideglusib ≥98%
- Packaging20mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT30356
- Product descriptionTideglusib
- Packaging10mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT30356
- Product descriptionTideglusib
- Packaging25mg
- Price$88.75
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT30356
- Product descriptionTideglusib
- Packaging50mg
- Price$137.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT30356
- Product descriptionTideglusib
- Packaging100mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT30356
- Product descriptionTideglusib
- Packaging250mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16727
- Product descriptionTideglusib ≥98%
- Packaging5mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16727
- Product descriptionTideglusib ≥98%
- Packaging10mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16727
- Product descriptionTideglusib ≥98%
- Packaging25mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16727
- Product descriptionTideglusib ≥98%
- Packaging50mg
- Price$129
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM141477
- Product description4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 98%
- Packaging100mg
- Price$209
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0613
- Product descriptionTideglusib 99.66%
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0613
- Product descriptionTideglusib 99.66%
- Packaging50mg
- Price$168
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5395 | 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione | 1g | $1286 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014171 | TIDEGLUSIB 95.00% | 5MG | $141.9 | 2021-12-16 | Buy |
| ApexBio Technology | B1539 | Tideglusib | 200mg | $330 | 2021-12-16 | Buy |
| Arctom | CFN60383 | Tideglusib ≥98% | 20mg | $208 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT30356 | Tideglusib | 10mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT30356 | Tideglusib | 25mg | $88.75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT30356 | Tideglusib | 50mg | $137.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT30356 | Tideglusib | 100mg | $225 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT30356 | Tideglusib | 250mg | $375 | 2021-12-16 | Buy |
| Cayman Chemical | 16727 | Tideglusib ≥98% | 5mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 16727 | Tideglusib ≥98% | 10mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16727 | Tideglusib ≥98% | 25mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 16727 | Tideglusib ≥98% | 50mg | $129 | 2024-03-01 | Buy |
| Chemenu | CM141477 | 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 98% | 100mg | $209 | 2021-12-16 | Buy |
| ChemScene | CS-0613 | Tideglusib 99.66% | 10mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-0613 | Tideglusib 99.66% | 50mg | $168 | 2021-12-16 | Buy |
Properties
Melting point :148 - 150oC
Boiling point :511.3±43.0 °C(Predicted)
Density :1.393
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :-1.51±0.20(Predicted)
color :white to beige
InChI :InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChIKey :PMJIHLSCWIDGMD-UHFFFAOYSA-N
SMILES :S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C1=C2C(C=CC=C2)=CC=C1
Boiling point :511.3±43.0 °C(Predicted)
Density :1.393
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :-1.51±0.20(Predicted)
color :white to beige
InChI :InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChIKey :PMJIHLSCWIDGMD-UHFFFAOYSA-N
SMILES :S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C1=C2C(C=CC=C2)=CC=C1
Safety Information
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Description
Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 . Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 μM without preincubation. Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.More related product prices
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![4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione](/ProductImageEN1/2024-08/small/c16eb91d-bcb9-4c50-a577-5a62140a321b.png){kind=small}
![4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione](https://img.chemicalbook.com/ProductImageEN/2018-8/small/2da68b40-4188-4530-b786-a1dff3bd4510.jpg){kind=small}