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ChemicalBook >> CAS DataBase List >> 6-Thioguanine

6-Thioguanine

6-Thioguanine price.
  • $5 - $1500
  • Product name: 6-Thioguanine
  • CAS: 154-42-7
  • MF: C5H5N5S
  • MW: 167.19
  • EINECS:205-827-2
  • MDL Number:MFCD00233553
  • Synonyms:2-Amino-1,7(9)-dihydro-purine-6-thione;2-amino-6-mercaptopurine (50X)*gamma-irradiated C;2-amino-6-mercaptopurine crystalline;2-Amino-6-purinethiol (6-Thioguanine);2-AMINO-6-MERCAPTOPURINE (50X)GAMMA-IRRA DIATED CEL;Tioguanine(Thioguanine);6-Thioguanine,~97%;6-THIOGUANIDE
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Frontier Specialty Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • SynQuest Laboratories
  • TCI Chemical
  • Tocris
  • Usbiological
Package
  • 2.5mg
  • 5MG
  • 25mg
  • 50mg
  • 100mg
  • 50
  • 200mg
  • 250mg
  • 0.500g
  • 500mg
  • 1g
  • 5g
  • 25g
  • 100G
  • ManufacturerAK Scientific
  • Product numberJ10163
  • Product description6-Thioguanine
  • Packaging100mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10163
  • Product description6-Thioguanine
  • Packaging1g
  • Price$68.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberB21280
  • Product description6-Thioguanine, 98%
  • Packaging1g
  • Price$85.4
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberB21280
  • Product description6-Thioguanine, 98%
  • Packaging5g
  • Price$298.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA393548
  • Product description6-Thioguanine 98+%
  • Packaging25mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA393548
  • Product description6-Thioguanine 98+%
  • Packaging100mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA393548
  • Product description6-Thioguanine 98+%
  • Packaging250mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA393548
  • Product description6-Thioguanine 98+%
  • Packaging1g
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA393548
  • Product description6-Thioguanine 98+%
  • Packaging5g
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015888
  • Product description6-THIOGUANINE 95.00%
  • Packaging5MG
  • Price$512
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015888
  • Product description6-THIOGUANINE 95.00%
  • Packaging1G
  • Price$735.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015888
  • Product description6-THIOGUANINE 95.00%
  • Packaging5G
  • Price$846.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4176
  • Product descriptionThioguanine
  • Packaging50mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4176
  • Product descriptionThioguanine
  • Packaging500mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR4016
  • Product description2-Amino-6-purinethiol
  • Packaging1g
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR4016
  • Product description2-Amino-6-purinethiol
  • Packaging5g
  • Price$56
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J10163 6-Thioguanine 100mg $39 2021-12-16 Buy
AK Scientific J10163 6-Thioguanine 1g $68.8 2021-12-16 Buy
Alfa Aesar B21280 6-Thioguanine, 98% 1g $85.4 2024-03-01 Buy
Alfa Aesar B21280 6-Thioguanine, 98% 5g $298.65 2024-03-01 Buy
Ambeed A393548 6-Thioguanine 98+% 25mg $5 2021-12-16 Buy
Ambeed A393548 6-Thioguanine 98+% 100mg $7 2021-12-16 Buy
Ambeed A393548 6-Thioguanine 98+% 250mg $12 2021-12-16 Buy
Ambeed A393548 6-Thioguanine 98+% 1g $27 2021-12-16 Buy
Ambeed A393548 6-Thioguanine 98+% 5g $97 2021-12-16 Buy
American Custom Chemicals Corporation API0015888 6-THIOGUANINE 95.00% 5MG $512 2021-12-16 Buy
American Custom Chemicals Corporation API0015888 6-THIOGUANINE 95.00% 1G $735.45 2021-12-16 Buy
American Custom Chemicals Corporation API0015888 6-THIOGUANINE 95.00% 5G $846.8 2021-12-16 Buy
ApexBio Technology A4176 Thioguanine 50mg $40 2021-12-16 Buy
ApexBio Technology A4176 Thioguanine 500mg $70 2021-12-16 Buy
Apolloscientific OR4016 2-Amino-6-purinethiol 1g $19 2021-12-16 Buy
Apolloscientific OR4016 2-Amino-6-purinethiol 5g $56 2021-12-16 Buy

Properties

Melting point :≥300 °C(lit.)
Density :1.483 (estimate)
refractive index :1.5605 (estimate)
storage temp. :2-8°C
solubility :Practically insoluble in water and in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides.
form :lyophilized powder
pka :pKa 8.22 (Uncertain)
Boiling point :555.4±42.0 °C(Predicted)
color :Yellow to green
Water Solubility :soluble
Merck :14,9337
BRN :157765
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month.
CAS DataBase Reference :154-42-7(CAS DataBase Reference)
EPA Substance Registry System :Thioguanine (154-42-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity. Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation. This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.

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