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ChemicalBook >> CAS DataBase List >> 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- price.
  • $28 - $7252.25
  • Product name: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
  • CAS: 404951-53-7
  • MF: C22H25N3O3
  • MW: 379.45
  • EINECS:
  • MDL Number:
  • Synonyms:2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-;Dacinostat(NVP-LAQ 824);LAQ-824;LAQ824 (Dacinostat);(E)-3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide;(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide;3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid;LAQ824(NVP-LAQ824,Dacinostat)
20 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • TRC
  • Usbiological
Package
  • 1mg
  • 1unit
  • 5mg
  • 10MG
  • 25mg
  • 50MG
  • 100MG
  • 250mg
  • 1G
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberX7530
  • Product descriptionDacinostat
  • Packaging5mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging10MG
  • Price$885.31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging50MG
  • Price$1370.41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging100MG
  • Price$2194.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging1G
  • Price$7252.25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4103
  • Product descriptionLAQ824(NVP-LAQ824,Dacinostat)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180988
  • Product descriptionDacinostat (NVP-LAQ824, LAQ824) >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180988
  • Product descriptionDacinostat (NVP-LAQ824, LAQ824) >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180988
  • Product descriptionDacinostat (NVP-LAQ824, LAQ824) >98%
  • Packaging1000mg
  • Price$2541.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43358
  • Product descriptionDacinostat
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43358
  • Product descriptionDacinostat
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16427
  • Product descriptionLAQ824 ≥95%
  • Packaging1mg
  • Price$35
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16427
  • Product descriptionLAQ824 ≥95%
  • Packaging5mg
  • Price$123
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16427
  • Product descriptionLAQ824 ≥95%
  • Packaging10mg
  • Price$210
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1974
  • Product descriptionDacinostat 98.45%
  • Packaging10mg
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1974
  • Product descriptionDacinostat 98.45%
  • Packaging50mg
  • Price$576
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7530 Dacinostat 5mg $280 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 10MG $885.31 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 50MG $1370.41 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 100MG $2194.5 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 1G $7252.25 2021-12-16 Buy
ApexBio Technology A4103 LAQ824(NVP-LAQ824,Dacinostat) 1unit $28 2021-12-16 Buy
Biorbyt Ltd orb180988 Dacinostat (NVP-LAQ824, LAQ824) >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb180988 Dacinostat (NVP-LAQ824, LAQ824) >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb180988 Dacinostat (NVP-LAQ824, LAQ824) >98% 1000mg $2541.5 2021-12-16 Buy
Biosynth Carbosynth FD43358 Dacinostat 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FD43358 Dacinostat 50mg $437.5 2021-12-16 Buy
Cayman Chemical 16427 LAQ824 ≥95% 1mg $35 2024-03-01 Buy
Cayman Chemical 16427 LAQ824 ≥95% 5mg $123 2024-03-01 Buy
Cayman Chemical 16427 LAQ824 ≥95% 10mg $210 2024-03-01 Buy
ChemScene CS-1974 Dacinostat 98.45% 10mg $216 2021-12-16 Buy
ChemScene CS-1974 Dacinostat 98.45% 50mg $576 2021-12-16 Buy

Properties

Density :1.290±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥17.45 mg/mL in DMSO
form :solid
pka :8.81±0.23(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

LAQ824 is a hydroxamate-based inhibitor of histone deacetylases (HDACs) with an IC50 value of 30 nM. It inhibits the growth of colon, breast, prostate, and non-small cell lung cancer cell lines at concentrations of less than 1 μM. LAQ824 augments the actions of fludarabine and imatinib mesylate in human leukemia cells. Through its effects on HDACs, LAQ824 induces acetylation of histones, α-tubulin, and heat shock protein 90 (Hsp90). Acetylation of Hsp90 blocks its chaperone function, resulting in changes in levels of several client proteins, including estrogen receptor-α, Hsp72, and Raf-1.

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