10-Propargyl-10-deazaaminopterin
|
- $45 - $4400
- Product name: 10-Propargyl-10-deazaaminopterin
- CAS: 146464-95-1
- MF: C23H23N7O5
- MW: 477.47
- EINECS:
- MDL Number:MFCD00920897
- Synonyms:N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid;10-Propargyl-10-deazaaminopterin;L-Glutamic acid, N-(4-(1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-;Unii-A8Q8I19Q20;FOLOTYN PRALATREXATE;N-(4-{1-[(2,4-diaMinopteridin-6-yl)Methyl]but-3-yn-1-yl}benzoyl)-L-glutaMic acid;N-[4-[1-[(2,4-DiaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]benzoyl]-L-glutaMic Acid;(2S)-2-(4-(1-(2,4-diaMinopteridin-6-yl)pent-4-yn-2-yl)benzaMido)pentanedioic acid
29 prices
Selected condition：
Brand
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TCI Chemical
- TRC
Package
- 10MG
- 10mM(in 1mL DMSO)
- 5MG
- 25MG
- 50mg
- 100MG
- 250mg
- 1g
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging5MG
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging25MG
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging100MG
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005288
- Product descriptionPRALATREXATE 95.00%
- Packaging10MG
- Price$2000
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005288
- Product descriptionPRALATREXATE 95.00%
- Packaging25MG
- Price$4400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4350
- Product descriptionPralatrexate
- Packaging10mM(in 1mL DMSO)
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4350
- Product descriptionPralatrexate
- Packaging10mg
- Price$224
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4350
- Product descriptionPralatrexate
- Packaging50mg
- Price$679
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23689
- Product descriptionPralatrexate ≥98%
- Packaging10mg
- Price$364
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23689
- Product descriptionPralatrexate ≥98%
- Packaging50mg
- Price$455
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23689
- Product descriptionPralatrexate ≥98%
- Packaging100mg
- Price$546
- Updated2024-03-01
- Buy
- ManufacturerChem-Impex
- Product number38204
- Product descriptionPralatrexate,98%(HPLC) 98%(HPLC)
- Packaging25MG
- Price$169.12
- Updated2021-12-16
- Buy
- ManufacturerChem-Impex
- Product number38204
- Product descriptionPralatrexate,98%(HPLC) 98%(HPLC)
- Packaging100MG
- Price$532
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0504
- Product descriptionPralatrexate 99.23%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0504
- Product descriptionPralatrexate 99.23%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0504
- Product descriptionPralatrexate 99.23%
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 5MG | $45 | 2021-12-16 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 25MG | $145 | 2021-12-16 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 100MG | $395 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005288 | PRALATREXATE 95.00% | 10MG | $2000 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005288 | PRALATREXATE 95.00% | 25MG | $4400 | 2021-12-16 | Buy |
| ApexBio Technology | A4350 | Pralatrexate | 10mM(in 1mL DMSO) | $182 | 2021-12-16 | Buy |
| ApexBio Technology | A4350 | Pralatrexate | 10mg | $224 | 2021-12-16 | Buy |
| ApexBio Technology | A4350 | Pralatrexate | 50mg | $679 | 2021-12-16 | Buy |
| Cayman Chemical | 23689 | Pralatrexate ≥98% | 10mg | $364 | 2024-03-01 | Buy |
| Cayman Chemical | 23689 | Pralatrexate ≥98% | 50mg | $455 | 2024-03-01 | Buy |
| Cayman Chemical | 23689 | Pralatrexate ≥98% | 100mg | $546 | 2024-03-01 | Buy |
| Chem-Impex | 38204 | Pralatrexate,98%(HPLC) 98%(HPLC) | 25MG | $169.12 | 2021-12-16 | Buy |
| Chem-Impex | 38204 | Pralatrexate,98%(HPLC) 98%(HPLC) | 100MG | $532 | 2021-12-16 | Buy |
| ChemScene | CS-0504 | Pralatrexate 99.23% | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0504 | Pralatrexate 99.23% | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0504 | Pralatrexate 99.23% | 50mg | $250 | 2021-12-16 | Buy |
Properties
Melting point :215 °C(dec.)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
Water Solubility :Insoluble in water
solubility :≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka :3.53±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
Water Solubility :Insoluble in water
solubility :≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka :3.53±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Pralatrexate, an injectable DHFR inhibitor, was launched for the treatment of patients with relapsed or refractory PTCL. PTCL is an aggressive form of non-Hodgkin’s lymphoma (NHL) characterized by the proliferation of abnormal T-lymphocytes that circulate in the peripheral bloodstream. The inhibition of the folate enzymes DHFR and thymidylate synthase is a well-validated method of cancer treatment. In vitro, pralatrexate is slightly less potent than MTX in inhibiting DHFR derived from murine leukemia L1210 cells (Ki = 18.2 pM vs. 5.75 pM) and human leukemia CCRF-CEM cells (Ki = 13.4 pM vs. 5.4 pM). However, it is transported into both types of cells with 10-fold higher efficiency than MTX, thereby providing a more potent inhibition of cell growth as compared with MTX. In vivo, intraperitonally administered pralatrexate at 60 mg/ kg twice weekly for three or four doses caused complete lymphoma regressions in 89, 56, and 30% of HT, RL, and SKI-DLBCL-1 xenografted mice, respectively, whereas a similar dosing of MTX at 40 mg/kg twice weekly did not produce complete regression. The posttreatment tumor diameter was also smaller in pralatrexate-treated animals.Related product price
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Suppliers and manufacturers
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Lianyungang happen teng technology co., LTD
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
