Methylene-bis(4-cyclohexylisocyanate)
Product identifier
- Product name: Methylene-bis(4-cyclohexylisocyanate)
- CBnumber: CB5412149
- CAS: 5124-30-1
- EINECS Number: 225-863-2
- Synonyms: RMDI,methylene-bis(4-cyclohexylisocyanate)
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Methylene-bis(4-cyclohexylisocyanate)
- Synonyms: RMDI,methylene-bis(4-cyclohexylisocyanate)
- CAS: 5124-30-1
- EC number: 225-863-2
- MF: C15H22N2O2
- MW: 262.35
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx) Combustible.
Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb?). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Moisture sensitive.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
protective clothing
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type: Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearancecolorless, to, light yellow liquid
- Odourodorless
- Odour ThresholdNot applicable
- pHNo data available
- Melting point/freezing pointMelting point/freezing point: 26 °C
- Initial boiling point and boiling range113 °C at 1.013 hPa
- Flash point200 °C - closed cup - DIN 51758
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure No data available
- Vapour density No data available
- Relative density1,066 g/cm3 at 25 °C - lit. 1,07 at 25 °C
- Water solubilityinsoluble
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperature 225 °C at 1.013 hPa
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 12,658 mPa.s at 55 °C
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
No data available
Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
Heat.
Strong heating.
Incompatible materials
Amines, Strong bases, Alcohols, Heavy metals
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityLC50 Inhalation - Rat - male and female - 4 h - 456 mg/m3 (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 7.000 mg/kg (OECD Test Guideline 402)
Result: Irritating to skin. - 4 h (OECD Test Guideline 404)
Result: Irritating to eyes. (OECD Test Guideline 405)
Result: May cause sensitization by skin contact. (OECD Test Guideline 406)
in vivo assay - Guinea pig
Result: May cause sensitization by inhalation. Remarks: (ECHA)
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative
Toxicity
No data available
(Regulation (EC) No. 440/2008, Annex, C.3)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 0 % - Not readily biodegradable. (Regulation (EC) No. 440/2008, Annex, C.4-D)
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available
Waste treatment methods
May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers; contact may cause fires or explosions. Reaction with moist air, water or alcohols. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones etc.
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
Waste DisposalMethylene bis(4-cyclohexylisocyanate) isdissolved in acetone or any other combustible solvent and burned in a chemicalincinerator equipped with an afterburner andscrubber.
UN number
ADR/RID: 2206 IMDG: 2206 IATA: 2206
UN proper shipping name
ADR/RID: ISOCYANATES, TOXIC, N.O.S. (Dicyclohexylmethane-4,4'-di-isocyanate) IMDG: ISOCYANATES, TOXIC, N.O.S. (Dicyclohexylmethane-4,4'-di-isocyanate) IATA: Isocyanates, toxic, n.o.s. (Dicyclohexylmethane-4,4'-di-isocyanate)
Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
Packaging group
ADR/RID: III IMDG: III IATA: III
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.