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??(???) | ??(P-??????????)??(BIS(P-CHLOROPHENYLDIGUANIDO)HEXANE); |
CAS ?? | 55-56-1 |
???(%) | 100% |
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0.000000000000000192 ㎜Hg (25 ℃, ???)
800 ㎎/? (20 ℃)
17.45 (???? ??? ?? ???? ?? ???)
1.39 (20 ℃)
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(>400℃)
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LD50 2515 ㎎/㎏ ??? : Rat
LD50 >2000 ㎎/㎏ ??? : Rabbit
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rabbit, highly irritating, OECD Guide-line 405 ??/????(IUCLID) Causes moderate eye irritation;? ??(NLM,TOMES)
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(?????-??? ?? 80? ??? ? 200mL? Maskin (5%? ?????? ??????)? ??? ??? ? ???? ? ???? ??? ? ??. ?? ??? ???? ??? ????? ?? ?? ????? ????? ????? ??? ????? ??? ??? ??? ????. ?? ???? ????, ? ??? ?? ? 12???? ????? ?? ????? ???. ?? CHG? ?? ???? ????? ????, CHG ????? ???? ???. ??? CHG? ??? ?? ??? ??? ?? ??? ?? ?????? ????. CHG? ??? ??? ???? ???? ARDS ???? ??? ??.)/CASE REPORTS/ ...An 80-yr-old woman with dementia accidentally ingested approximately 200 mL of Maskin (5% /chlorhexidine gluconate/ (CHG)) in a nursing home and then presumably aspirated gastric contents. She was intubated for airway protection in the nearest hospital and referred to our critical care unit because of hypotension and rapid deterioration of consciousness. Despite intensive treatment, the patient died of acute respiratory distress syndrome (ARDS) 12 hr after ingestion. The serum concentration of CHG was markedly high, although CHG reportedly has poor enteral absorption. We suspect the CHG was absorbed through the pulmonary alveoli following aspiration, not from the gastrointestinal tract. CHG has the potential for fatal ARDS when aspiration occurs following ingestion. /Chlorhexidine gluconate/ (HSDB; Vet Hum Toxicol )
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LC50 1.4 ㎎/? 96 hr Brachydanio rerio
LC50 0.25 ㎎/? 48 hr Daphnia magna
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0 (%) 28 day (a closed bottle test)
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3077
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9
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