Hexamethylphosphoramide
Product identifier
- Product name: Hexamethylphosphoramide
- CBnumber: CB1177006
- CAS: 680-31-9
- EINECS Number: 211-653-8
- Synonyms: HMPA,HEXAMETHYLPHOSPHORAMIDE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
Label elements
Pictogram(s)
- Signal wordDanger
H340 May cause genetic defects
H350 May cause cancer
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Hexamethylphosphoramide
- Synonyms: HMPA,HEXAMETHYLPHOSPHORAMIDE
- CAS: 680-31-9
- EC number: 211-653-8
- MF: C6H18N3OP
- MW: 179.2
Description of first aid measures
If inhaledRefer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; dyspnea (breathing difficulty); abdominal pain; [potential occupational carcinogen] Target Organs: Eyes, skin, respiratory system, central nervous system, gastrointestinal tract (NIOSH, 2016)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and ExcretionSeventy percent of (32)p-labeled hexamethylphosphoramide given ip was excreted within 20 hr by rats & mice as (32)p. hexamethylphosphoramide is excreted in milk of cows following its oral admin.
Extinguishing media
Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific Hazards Arising from the Chemical
This chemical is combustible. (NTP, 1992)
Advice for firefighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Ventilation along the floor.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
Control parameters
Occupational Exposure limit valuesTLV: (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); carcinogen category: 2; germ cell mutagen group: 2
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety spectacles or face shield.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateliquid
- ColourColorless to light yellow liquid
- Odour
AROMATIC ODOR
- Melting point/freezing point
186°C(lit.)
- Boiling point or initial boiling point and boiling range
230-232°C/740mmHg(lit.)
- Flammability
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
144°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- SolubilityChloroform (Soluble), Methanol (Slightly)
- Partition coefficient n-octanol/water
no data available
- Vapour pressure0.07 mm Hg ( 25 °C)
- Density and/or relative density
1.03g/mLat 25°C(lit.)
- Relative vapour density
6.18 (vs air)
- Particle characteristics
no data available
Reactivity
NIOSH considers hexamethyl phosphoramide to be a potential occupational carcinogen.
Decomposes on heating and on burning. This produces toxic fumes including phosphorus oxides and nitrogen oxides.
Chemical stability
Reacts upon heating with org acids to form the dimethylamide of the org acid
Possibility of hazardous reactions
HEXAMETHYLPHOSPHORAMIDE may react with strong oxidizing agents and strong acids (NTP, 1992). Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Conditions to avoid
no data available
Incompatible materials
Oxidizers, strong acids, chemically active metals (e.g., potassium, sodium, magnesium, zinc).
Hazardous decomposition products
When heated to decomposition it emits very toxic fume of /phosphine, phosphorus oxides and nitrogen oxides/.
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogeniciy of hexamethylphosphoramide were available. There is sufficient evidence in experimental animals for the carcinogenicity of hexamethylphosphoramide. Overall evaluation: Hexamethylphosphoramide is possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
No information is available on the reproductive or developmental effects of hexamethylphosphoramide in humans. Animal studies have reported reproductive effects, including reduced fertility, a reduction in sperm count, and significantly reduced testicular weights from oral exposure to hexamethylphosphoramide.
STOT-single exposure
Exposure to high concentrations could cause effects on the nervous system, kidneys and respiratory tract.
STOT-repeated exposure
The substance may have effects on the respiratory tract, kidneys and testes. This substance is possibly carcinogenic to humans. May cause genetic damage in humans.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
Based on a measured log Kow of 0.28(2) and a regression derived equation(1), the bioconcentration factor (BCF) can be estimated to be about 0.96(SRC). This BCF value suggests that hexamethylphosphoramide may not bioconcentrate in aquatic organisms(SRC).
Mobility in soil
Based on a measured log Kow of 0.28(2), the Koc for hexamethylphosphoramide can be estimated to be 34 using a recommended regression derived equation(1,SRC). This Koc value suggests that hexamethylphosphoramide has very high mobility in soil and may leach(3).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.See ICSC 0695.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.