BROMODICHLOROMETHANE
Product identifier
- Product name: BROMODICHLOROMETHANE
- CBnumber: CB2186236
- CAS: 75-27-4
- EINECS Number: 200-856-7
- Synonyms: Bromodichloromethane,Dichloroiodomethane
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: BROMODICHLOROMETHANE
- Synonyms: Bromodichloromethane,Dichloroiodomethane
- CAS: 75-27-4
- EC number: 200-856-7
- MF: CHBrCl2
- MW: 163.83
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides, Hydrogen chloride gas, Hydrogen bromide gas
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact
Material: Fluorinated rubber Minimum layer thickness: 0,7 mm Break through time: 120 min
Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Information on basic physicochemical properties
- Appearancecolorless liquid, clear
- OdourNo data available
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointMelting point/range: -55 °C - lit.
- Initial boiling point and boiling range87 °C - lit.
- Flash point87-89°C
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure 50 at 20 °C (Dreisbach, 1952)
- Vapour density No data available
- Relative density1,98 g/cm3 at 25 °C
- Water solubilityinsoluble
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- Henry's Law ConstantIn seawater (salinity 30.4‰): 5.52, 10.51, and 18.97 at 0, 10, and 20 °C, respectively (Moore et al., 1995)
Other safety information
No data available
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
No data available
Incompatible materials
Strong oxidizing agents, Strong bases, Magnesium
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas, Hydrogen bromide gas
Other decomposition products - No data available In the event of fire: see section 5
Information on toxicological effects
Acute toxicityRemarks: Brain and Coverings:Changes in circulation (hemorrhage,thrombosis, etc.). Liver:Fatty liver degeneration. Blood: Hemorrhage.
TDLo Oral - Rat - 40 mg/kg
Remarks: Nutritional and Gross Metabolic:Weight loss or decreased weight gain. TDLo Oral - Rat - 35 mg/kg
Remarks: Liver:Other changes. Kidney, Ureter, Bladder:Other changes. TDLo Oral - Rat - 20,5 mg/kg
Remarks: Liver:Liver function tests impaired. TDLo Oral - Rat - 400 mg/kg
Remarks: Biochemical:Enzyme inhibition, induction, or change in blood or tissue lev hydroxylation, etc.). Liver:Other changes.
TDLo Oral - Rat - 2.000 mg/kg
Remarks: Kidney, Ureter, Bladder:Changes in both tubules and glomeruli. Kidney, Ureter, Bladder:Other changes in urine composition.
TDLo Oral - Rat - 9.828 mg/kg
Remarks: Blood:Changes in erythrocyte (RBC) count. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Biochemical:Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases.
TDLo Oral - Rat - 2.904,6 mg/kg
Remarks: Behavioral:Fluid intake. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Nutritional and Gross Metabolic:Dehydration.
TDLo Oral - Rat - 5.366,9 mg/kg
Remarks: Kidney, Ureter, Bladder:Changes in kidney weight. Endocrine:Other changes. Skin and Appendages: Other: Hair.
TDLo Oral - Rat - 3.127 mg/kg
Remarks: Behavioral:Fluid intake. Nutritional and Gross Metabolic:Weight loss or decreased weight gain.
TDLo Oral - Rat - 20.075 mg/kg
Remarks: Liver:Fatty liver degeneration. Liver:Other changes. Liver:Changes in liver weight.
TDLo Oral - Rat - 5.670 mg/kg
Remarks: Liver:Changes in liver weight. Blood:Changes in serum composition (e.g., TP, bilirubin, cholesterol). Nutritional and Gross Metabolic:Weight loss or decreased weight gain.
TDLo Oral - Rat - 742 mg/kg
Remarks: Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Behavioral:Food intake (animal).
TDLo Oral - Rat - 2.000 mg/kg
Remarks: Kidney, Ureter, Bladder:Changes in both tubules and glomeruli. Kidney, Ureter, Bladder:Other changes in urine composition.
TDLo Oral - Rat - 375 mg/kg
Remarks: Endocrine:Estrogenic. Blood:Changes in serum composition (e.g., TP, bilirubin, cholesterol).
TDLo Oral - Rat - 750 mg/kg
Remarks: Biochemical:Enzyme inhibition, induction, or change in blood or tissue lev hydroxylation, etc.). Liver:Changes in liver weight. Kidney, Ureter, Bladder:Other changes. TDLo Oral - Mouse - 1.000 mg/kg
Remarks: Kidney, Ureter, Bladder:Renal function tests depressed. Blood:Changes in serum composition (e.g., TP, bilirubin, cholesterol).
TDLo Oral - Mouse - 750 mg/kg
Remarks: Biochemical:Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases. Biochemical:Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases. Liver:Changes in liver weight.
TDLo Oral - Rabbit - 59,5 mg/kg
Remarks: Behavioral:Fluid intake. Behavioral:Food intake (animal).
Limited evidence of carcinogenicity in animal studies
IARC: 2B - Group 2B: Possibly carcinogenic to humans (Bromodichloromethane) IARC: 2B - Group 2B: Possibly carcinogenic to humans (Bromodichloromethane)
prolonged or repeated exposure can cause:, Nausea, Dizziness, Headache, narcosis
Toxicity
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.