Isobutyl 1,2-dihydro-2-isobutoxy-1-quinoline-carboxylate
Product identifier
- Product name: Isobutyl 1,2-dihydro-2-isobutoxy-1-quinoline-carboxylate
- CBnumber: CB6224549
- CAS: 38428-14-7
- EINECS Number: 253-925-9
- Synonyms: IIDQ,1-Isobutoxycarbonyl-2-isobutoxy-1,2-dihydroquinoline
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Isobutyl 1,2-dihydro-2-isobutoxy-1-quinoline-carboxylate
- Synonyms: IIDQ,1-Isobutoxycarbonyl-2-isobutoxy-1,2-dihydroquinoline
- CAS: 38428-14-7
- EC number: 253-925-9
- MF: C18H25NO3
- MW: 303.4
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx)
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | |||
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Avoid exposure - obtain special instructions before use. Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentSafety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Information on basic physicochemical properties
- Appearancecolorless clear, viscous, liquid
- OdourNo data available
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointNo data available
- Initial boiling point and boiling range 140 - 142 °C at 0,3 hPa
- Flash point113 °C - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure No data available
- Vapour density No data available
- Relative density1,022 g/mL at 25 °C No data available
- Water solubilityNo data available
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
No data available
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
No data available
Incompatible materials
acids
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicity(Calculation method)
LD50 Oral - Rat - male and female - 262 mg/kg (quinoline) (OECD Test Guideline 401)
Symptoms: Nausea, Vomiting, Gastrointestinal disturbance Symptoms: Possible damages:, mucosal irritations
Acute toxicity estimate Dermal - > 2.000 mg/kg (Calculation method)
LD50 Dermal - Rat - male and female - 1.377 mg/kg (quinoline) (OECD Test Guideline 402)
Result: negative
(OECD Test Guideline 429)
Test Type: Mutagenicity (mammal cell test): chromosome aberration. (quinoline)
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Result: Positive results were obtained in some in vitro tests. Remarks: (ECHA)
Test Type: Ames test (quinoline)
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: Mutagenicity (Salmonella typhimurium - reverse mutation assay)
Result: Positive results were obtained in some in vitro tests. Remarks: (ECHA)
Test Type: sister chromatid exchange assay (quinoline)
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Result: Positive results were obtained in some in vitro tests. Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test (quinoline)
Test system: Mouse lymphoma test
Metabolic activation: without metabolic activation Result: positive
Remarks: (ECHA) (quinoline)
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection
Result: positive Remarks: (ECHA)
Toxicity
(OECD Test Guideline 203)
Persistence and degradability
Biodegradability Result: 100 % - Readily biodegradable.
(OECD Test Guideline 301D)
Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 6 Weeks
at 25 °C - 0,8 mg/l(quinoline)
Mobility in soil
No data available
Bioconcentration factor (BCF): 1,6 - 2,5 Elimination: yes
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Discharge into the environment must be avoided.
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
| 14.3 | IATA: Not dangerous goods Transport hazard class(es) | |
| | ADR/RID: - IMDG: - | IATA: - |
| 14.4 | Packaging group ADR/RID: - IMDG: - | IATA: - |
| 14.5 | Environmental hazards ADR/RID: no IMDG Marine pollutant: no | IATA: no |
14.6 Special precautions for user
Further information
Not classified as dangerous in the meaning of transport regulations.
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.