2-Oxetanone
Product identifier
- Product name: 2-Oxetanone
- CBnumber: CB0275433
- CAS: 57-57-8
- EINECS Number: 200-340-1
- Synonyms: oxetan-2-one,β-propiolactone
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Acute toxicity - Category 2, Inhalation
Carcinogenicity, Category 1B
Label elements
Pictogram(s)
- Signal wordDanger
H227 Combustible liquid
H315 Causes skin irritation
H319 Causes serious eye irritation
H330 Fatal if inhaled
H350 May cause cancer
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P284 Wear respiratory protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P320 Specific treatment is urgent (see … on this label).
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P203 Obtain, read and follow all safety instructions before use.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P320 Specific treatment is urgent (see ... on this label).
P318 IF exposed or concerned, get medical advice.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 2-Oxetanone
- Synonyms: oxetan-2-one,β-propiolactone
- CAS: 57-57-8
- EC number: 200-340-1
- MF: C3H4O2
- MW: 72.06
Description of first aid measures
If inhaledFresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
The toxicity potential of this material via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen. (EPA, 1998)
Indication of any immediate medical attention and special treatment needed
In the event of an emergency, remove the victim from further exposure, send for medical assistance, and initiate emergency procedures. If a worker had contact with beta-propiolactone, OSHA requires that that the worker shower as soon as possible, unless contraindicated by physical injuries.
Extinguishing media
Use alcohol foam.
Specific Hazards Arising from the Chemical
Containers may explode. When heated to decomposition, it emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures. (EPA, 1998)
Advice for firefighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
NFPA 704
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: self-contained breathing apparatus. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
Precautions for safe handling
NO open flames. Above 74°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Cooled. Well closed. Ventilation along the floor.MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED .
Control parameters
Occupational Exposure limit valuesTLV: 0.5 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); carcinogen category: 2
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety goggles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateLiquid
- ColourColorless liquid with a sweet but irritating odor
- Odour
PUNGENT
- Melting point/freezing point
-12°C(lit.)
- Boiling point or initial boiling point and boiling range
165°C(lit.)
- Flammability
Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.
- Lower and upper explosion limit/flammability limit
LOWER FLAMMABLE LIMIT: 2.9%
- Flash point
74°C(lit.)
- Auto-ignition temperature
no data available
- Decomposition temperature
155°C
- pH
no data available
- Kinematic viscosity
no data available
- SolubilityMiscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983)
- Partition coefficient n-octanol/water
log Kow= 0.462 (est)
- Vapour pressure3 at 25 °C (NIOSH, 1997)
- Density and/or relative density
1.146
- Relative vapour density
2.5 (NTP, 1992) (Relative to Air)
- Particle characteristics
no data available
Reactivity
NIOSH considers beta-propiolactone to be a potential occupational carcinogen.
The substance may polymerize due to warming. This generates fire or explosion hazard.
Chemical stability
Stable when stored at +5 deg c in glass containers
Possibility of hazardous reactions
FIRE HAZARD: MODERATE, WHEN EXPOSED TO HEAT OR FLAME .BETA-PROPIOLACTONE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical may be incompatible with alkalis.
Conditions to avoid
no data available
Incompatible materials
Acetates, halogens, thiocyanates, thiosulfates [Note: May polymerize upon storage].
Hazardous decomposition products
no data available
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
A3; Confirmed animal carcinogen with unknown relevance to humans.
Reproductive toxicity
No information is available on the reproductive or developmental effects of beta-propiolactone in humans or animals.
STOT-single exposure
The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract.
STOT-repeated exposure
This substance is probably carcinogenic to humans.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying.
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
The rapid aqueous hyrolysis of beta-propiolactone precludes the importance of bioconcentration. (SRC)
Mobility in soil
The rapid aqueous hyrolylsis of beta-propiolactone precludes the importance of leaching. (SRC)
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3382 (For reference only, please check.)
IMDG: UN3382 (For reference only, please check.)
IATA: UN3382 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)
IMDG: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)
IATA: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.