2-HYDROXYPROPIONITRILE
Product identifier
- Product name: 2-HYDROXYPROPIONITRILE
- CBnumber: CB9446861
- CAS: 42492-95-5
- EINECS Number: 255-852-8
- Synonyms: 2-HYDROXYPROPIONITRILE,DL-lactonitrile
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 2, Dermal
Acute toxicity - Category 3, Inhalation
Label elements
Pictogram(s)
-
Signal word
Danger
H301 Toxic if swallowed
H310 Fatal in contact with skin
H331 Toxic if inhaled
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 2-HYDROXYPROPIONITRILE
- Synonyms: 2-HYDROXYPROPIONITRILE,DL-lactonitrile
- CAS: 42492-95-5
- EC number: 255-852-8
- MF: C3H5NO
- MW: 71.08
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
Extremely toxic by oral, skin, or eye contact. (EPA, 1998)
Indication of any immediate medical attention and special treatment needed
Rapid support of respiration and circulation is essential to successful treatment of cyanide intoxication. Massive cyanide overdoses have survived with only good supportive care. Immediate attention should be directed toward assisted ventilation, administration of 100% oxygen, insertion of intravenous lines, and institution of cardiac monitoring. Obtain an arterial blood gas immediately and correct any severe metabolic acidosis (pH below 7.15). Oxygen (100%) should be used routinely in moderate or severely symptomatic patients even in the presence of a normal pO2, since 100% O2 increases O2 delivery, may reactivate cyanide-inhibited mitochondrial enzymes, and potentiates the effect of thiosulfate. Avoid mouth to mouth resuscitation during CPR in order to prevent self poisoning. Cyanides
Extinguishing media
Foam, carbon dioxide, dry chemical. (EPA, 1998)
Specific Hazards Arising from the Chemical
Cyanide fumes released when heated to decomposition. Avoid alkali, oxidizing material. (EPA, 1998)
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical state
Straw colored liquid. Used as a solvent /intermediate in production of ethyl lactate and lactic acid. (EPA, 1998)
- Colour
YELLOW LIQUID
- Odour
no data available
- Melting point/freezing point
-40°C
- Boiling point or initial boiling point and boiling range
90°C17 mm Hg(lit.)
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
64.7°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
greater than or equal to 100 mg/mL at 73° F (NTP, 1992)
- Partition coefficient n-octanol/water
log Kow= -0.94
- Vapour pressure
10 mm Hg at 165.2° F (EPA, 1998)
- Density and/or relative density
0.991 g/mL at 20°C(lit.)
- Relative vapour density
2.45 (EPA, 1998) (Relative to Air)
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
IT HAS MODERATE FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME ...LACTONITRILE is incompatible with strong acids, strong bases and strong reducing agents. It is also incompatible with strong oxidizers. In the presence of alkali, it evolves toxic compounds. (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Evolves hydrocyanic acid in presence of alkali.
Hazardous decomposition products
When heated to decomp, it releases highly toxic cyanide fumes.
Acute toxicity
- Oral: LD50 Rat oral 21 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: TLm Pimephales promelas (fathead minnow) 0.9 mg/l/96 hr. /Conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: The relatively low molecular weight hydrocarbon structure of 2-hydroxypropanenitrile suggests that biodegradation in soil and water is expected to be an important fate process(1). One screening study has demonstrated that 2-hydroxypropanenitrile was readily degraded in Ohio River water in the US(2), although this process could have been hydrolysis. Using Ohio River water as inoculum (with no special acclimation) and an aerobic test system, theoretical BODs of 50% and 70% were measured for 2-hydroxypropanenitrile after 2 and 5 day inoculation periods, respectively, at concns of 0.4-15 mg/l(2); re-dosing the system resulted in a 60% theoretical BOD(2). An activated sludge system that was acclimated to 2-hydroxypropanenitrile experienced a 87-98% BOD removal over a 4 week operation period while receiving influent 2-hydroxypropanenitrile levels that averaged 88 mg/l(3).
Bioaccumulative potential
An estimated BCF of 3 was calculated for 2-hydroxypropanenitrile(SRC), using a log Kow of -0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. 2-Hydroxypropanenitrile hydrolyzes in water(4) which suggests that bioconcentration in aquatic organisms should not be environmentally important(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-hydroxypropanenitrile can be estimated to be about 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-hydroxypropanenitrile is expected to have very high mobility in soil. 2-Hydroxypropanenitrile hydrolyzes in water(3) which suggests that leaching in soil is likely to occur(SRC).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3276 (For reference only, please check.)
IMDG: UN3276 (For reference only, please check.)
IATA: UN3276 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: NITRILES, LIQUID, TOXIC, N.O.S. (For reference only, please check.)
IMDG: NITRILES, LIQUID, TOXIC, N.O.S. (For reference only, please check.)
IATA: NITRILES, LIQUID, TOXIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.