1,2,3,4-Tetrachlorobenzene
Product identifier
- Product name: 1,2,3,4-Tetrachlorobenzene
- CBnumber: CB9854048
- CAS: 634-66-2
- EINECS Number: 211-214-0
- Synonyms: 1,2,3,4-Tetrachlorobenzene,Tetrachlorobenzene
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Label elements
Pictogram(s)
- Signal wordWarning
H302 Harmful if swallowed
H410 Very toxic to aquatic life with long lasting effects
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 1,2,3,4-Tetrachlorobenzene
- Synonyms: 1,2,3,4-Tetrachlorobenzene,Tetrachlorobenzene
- CAS: 634-66-2
- EC number: 211-214-0
- MF: C6H2Cl4
- MW: 215.89
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
ACUTE/CHRONIC HAZARDS: This compound may cause irritation of the skin. (NTP, 1992)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and ExcretionThree tetrachlorobenzene (TCB) congeners (1,2,3,4- 1,2,3,5- and 1,2,4,5-tetrachlorobenzene) were administered daily by gavage to pregnant Sprague-Dawley rats at levels of 50, 100, or 200 mg/kg from day 6-15 of gestation. Residues of all three congeners were found in maternal and fetal tissues but generally the amounts of the 1,2,4,5- isomer were about 100 times higher than the other two.
Extinguishing media
Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific Hazards Arising from the Chemical
This chemical is probably combustible. (NTP, 1992)
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
NFPA 704
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical stateneat
- ColourWhite crystals or needles
- Odour
no data available
- Melting point/freezing point
44-48°C
- Boiling point or initial boiling point and boiling range
254°C(761 torr)
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
111.9°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility0.0028g/l
- Partition coefficient n-octanol/water
log Kow= 4.64
- Vapour pressure1.5 (extrapolated from vapor pressures determined at higher temperatures, Tesconi andYalkowsky, 1998)
- Density and/or relative density
1,73 g/cm3
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
Simple aromatic halogenated organic compounds, such as 1,2,3,4-TETRACHLOROBENZENE, are very unreactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Conditions to avoid
no data available
Incompatible materials
In mfr of sodium salt of trichlorophenol, sodium hydroxide, methyl alcohol & tetrachlorobenzene were heated. during heating process, pressure suddenly incr rapidly & explosion occurred. tetrachlorobenzene
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen chloride/.
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 1.1 mg/l 96 hr flow-through bioassay, wt 0.12 g, water hardness 45.5 mg/l CaCO3, temp: 25 +/- 1 deg C, pH 7.5, dissolved oxygen greater than 60% of saturation
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
A 0% theoretical BOD in sludge over a 4 week incubation period suggests that biodegradation of 1,2,3,4-tetrachlorobenzene will be slow(1). 1,2,3,4-Tetrachlorobenzene was biodegraded by an acclimated anaerobic sediment slurry obtained from the Tsurumi River, Japan(2). The first-order biodegradation rate constant was 0.038 days-1, corresponding to a half-life of about 18 days(2). The half-life of 1,2,3,4-tetrachlorobenzene in sewage sludge amended soil was 34.5 days(3). An enriched microbial culture derived from sediment of the Rhine River reductively dechlorinated 1,2,3,4-tetrachlorobenzene to 1,2,4-trichlorobenzene in 280 days after a lag period of 47 days(4).
Bioaccumulative potential
BCF values of 520 to 1,560 were measured in carp exposed to 10 ug/l of 1,2,3,4-tetrachlorobenzene during a 6 week incubation period and BCF values of 490 to 1,700 were measured in carp exposed to 1 ug/l of 1,2,3,4-tetrachlorobenzene during a 6 week incubation period(1). Mean log BCF values of 3.7-4.1 were measured for rainbow trout exposed to 1,2,3,4-tetrachlorobenzene(2). A mean log BCF value of 3.5 was measured in fathead minnows exposed to 1,2,3,4-tetrachlorobenzene for 2-120 hours(3). A mean BCF value of 5,200 was reported for rainbow trout exposed to low levels of 1,2,3,4-tetrachlorobenzene for 119 days and a mean BCF value of 12,000 was reported for rainbow trout exposed to high concns of 1,2,3,4-tetrachlorobenzene for 119 days(4). According to a classification scheme(5), these BCF values suggest that bioconcentration in aquatic organisms is high.
Mobility in soil
A log Koc value of 3.8(1) was reported for 1,2,3,4-tetrachlorobenzene in soils and log Koc values of 3.5 to 3.8 were reported in sandy and clay loams(2). A log Koc value of 4.4 was reported for 1,2,3,4-tetrachlorobenzene in sediment obtained from Ise Bay, Japan(3) and a log Koc value of 4.7 was reported from sediment of Lake Oostvaardersplassen, Netherlands(4). According to a recommended classification scheme(5), these Koc values suggest that 1,2,3,4-tetrachlorobenzene has low mobility in soil.
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.