天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Definitions >>article

Definitions

Download PDF

Monomethyl Auristatin E

Published:2 February 2020 DOI: 10.32388/hcrd1w

Abstract

A dolastatin-10 peptide derivative with potent antimitotic activity and potential antineoplastic activity as part of an antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) binds to tubulin, blocks tubulin polymerization, and inhibits microtubule formation, which results in both disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. T o minimize toxicity and maximize efficacy, MMAE is conjugated, via a cleavable peptide linker, to a monoclonal antibody that specifically targets a patient's tumor. T he linker is stable in the extracellular milieu but is readily cleaved to release MMAE following binding and internalization of the ADC by the target cells. Qeios · Definition, February 2, 2020

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
MonoMethyl auristatin E 474645-27-7 C39H67N5O7 292 suppliers $49.00-$3260.00
dolastatin 10 110417-88-4 C42H68N6O6S 93 suppliers Inquiry
Auristatin E 160800-57-7 C40H69N5O7 78 suppliers Inquiry
Monomethyl auristatin E (MMAE) hydrochloride 1359995-63-3 C39H68ClN5O7 2 suppliers Inquiry

Similar articles

IF:4.6

Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates

iScience Zhiwen Fu , Chen Gao ,etc Published: 20 October 2023
IF:2.7

Acute oral toxicity of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether.

Bulletin of Environmental Contamination and Toxicology T Kawamoto, K Matsuno,etc Published: 1 April 1990
IF:3.3

Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis

Reproductive toxicology Emily Hanson Scofield , W. Matthew Henderson ,etc Published: 1 November 2006

Latest Papers

Nickel Sulfate

Published: 8 February 2020

L-Tyrosine

Published: 7 February 2020