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Reproductive toxicology

Reproductive toxicology

IF: 3.29
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Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis

Published:1 November 2006 DOI: 10.1016/j.reprotox.2006.05.005 PMID: 16829022
Emily Hanson Scofield , W. Matthew Henderson , Amy B. Funk , Gary L. Anderson , Mary Alice Smith

Abstract

Diethylene glycol monomethyl ether (DEGME), ethylene glycol monomethyl ether (EGME) and their common metabolite, methoxyacetic acid (MAA) have been associated with adverse reproductive effects. The objective of this research is to investigate the effects of DEGME, EGME and MAA on in vitro chondrogenesis and the mechanisms by which these effects occur. Micromass cultures were exposed to DEGME, EGME or MAA for 5 days and proteoglycan abundance and cell proliferation determined. Longer-term 9- and 14-day cultures were exposed to MAA and apoptosis analyzed. All three chemicals decreased proteoglycan abundance and cell proliferation at the highest dose tested (100?μL/mL). However, only MAA showed a dose-dependent effect for both parameters at 0.01, 10, and 100?μL/mL. Furthermore, micromass cultures show an increase in apoptotic cells which when treated with MAA suggest that cell death could result from induced apoptosis. These results suggest that effects of DEGME and EGME are the result of generalized toxicity, but their metabolite MAA induces mitochondrial-mediated apoptosis during in vitro chondrogenesis.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Methyl acetoacetate 105-45-3 C5H8O3 753 suppliers $5.00-$780.00
2-Methoxyethanol 109-86-4 C3H8O2 590 suppliers $11.00-$6520.00
Diethylene glycol monomethyl ether 111-77-3 C5H12O3 524 suppliers $10.60-$1346.00
Methoxyacetic acid 625-45-6 C3H6O3 353 suppliers $19.00-$1024.78

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