天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Asian Pacific journal of tropical biomedicine >>article
Asian Pacific journal of tropical biomedicine

Asian Pacific journal of tropical biomedicine

IF: 1.7
Download PDF

Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats

Published:1 January 2020 DOI: 10.4103/2221-1691.273090
A. Alkaladi,?H. Ali,?A. Abdelazim,?M. Afifi,?M. Baeshen,?A. Al-Farga

Abstract

Objective: To investigate the molecular mechanisms of the anti-obese effect of raspberry ketone against high-fat diet fed rats. Methods: Fifty adult male rats were randomly assigned to receive a standard diet, a high fat diet, and the high-fat diet and 0.5%, 1% or 2% raspberry ketone. Body weight, biochemical parameters and gene expression of CCAAT enhancer-binding protein (C/EBP)δ, fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), peroxisome proliferator-activated receptor alpha (PPAR-α), hormone-sensitive lipase (HSL) and hepatic carnitine palmitoyltransferase 1 A (CPT1A) were investigated. Results: Body weight, blood glucose, insulin, total lipids, triacylglycerols, total cholesterol and low-density lipoprotein cholesterol were increased in high-fat diet fed rats. These high fat diet-induced changes were attenuated by treatment with raspberry ketone. High-density lipoprotein cholesterol was decreased in highfat diet fed rats but increased in rats treated with raspberry ketone. Molecular investigations showed induction of gene expression of C/EBP-δ, FAS, ACC, CPT1A and inhibition of gene expression of PPAR-α and HSL in high-fat diet fed rats as compared with control. Raspberry ketone treament reversed these changes except CPT1A. Conclusions: Raspberry ketone can prevent obesity induced by a high-fat diet in rats by induction of the expression of enzymes, controlling lipolysis and fatty acids β oxidation as well as inhibition of gene expressions of adipogenic factors.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Raspberry Ketone 5471-51-2 C10H12O2 762 suppliers $5.00-$963.00

Similar articles

IF:5.6

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

International Journal of Molecular Sciences Elena A Tukhovskaya, Elvira R Shaykhutdinova,etc Published: 11 December 2022
IF:5.3

Potentials of Raspberry Ketone as a Natural Antioxidant.

ACS Applied Nano Materials Sung Ho Lim, Chang-Ik Choi,etc Published: 18 March 2021
IF:5.4

Efficient bioconversion of raspberry ketone in Escherichia coli using fatty acids feedstocks.

ACS Applied Energy Materials Chen Chang, Bo Liu,etc Published: 12 March 2021