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FARMACIA

FARMACIA

IF: 1.39
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DENATONIUM BENZOATE ATTENUATES INFLAMMATION AND PAIN AND DECREASES PGE2 LEVELS IN RATS

Published:25 April 2022 DOI: 10.31925/farmacia.2022.2.6
Vesela Kokova

Abstract

Denatonium benzoate (DB) is an agonist of bitter taste receptors (TAS2Rs). TAS2Rs are detected in many non-sensory tissues, and their activation could lead to different effects. The aim of our study was to evaluate the anti-inflammatory, antihyperalgesic activity of DB and the changes in plasma levels of PGE2 after administration of DB. Male Wistar rats were divided into 5 groups (n = 6) and treated intraperitoneally (i.p.) with: saline, diclofenac sodium 25 mg/kg bw, DB 10 mg/kg bw and DB 15 mg/kg bw, respectively. The following methods were applied: i) carrageenan-induced paw oedema; ii) carrageenan-induced hyperalgesia and iii) enzyme-linked immunosorbent assay (ELISA). DB in doses of 10 and 15 mg/kg bw significantly inhibited paw oedema at the 2 nd , 3 rd and 4 th hour after carrageenan injection. The anti-hyperalgesic activity was observed in rats treated with 10 and 15 mg/kg bw DB only at the 4 th hour after carrageenan administration. The levels of PGE2 significantly decreased in groups treated with DB in both doses. Our results indicate that DB possesses anti-inflammatory and anti-hyperalgesic effects in the carrageenan-induced models of exudative inflammation and hyperalgesia. This activity may be related to decreased PGE2 levels. caragenanului. Nivelurile de PGE2 au sc?zut semnificativ ?n grupurile tratate cu DB ?n ambele doze. Rezultatele noastre indic? faptul c? DB posed? efecte antiinflamatorii ?i anti-hiperalgice ?n modelele de inflama?ie exudativ? ?i hiperalgezie induse de caragenan. Aceast? activitate poate fi legat? de sc?derea nivelurilor de PGE2.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Diclofenac sodium 15307-79-6 C14H10Cl2NNaO2 946 suppliers $14.00-$3326.40
Denatonium Benzoate 3734-33-6 C28H34N2O3 547 suppliers $11.00-$1500.00
Prostaglandin E2 363-24-6 C20H32O5 331 suppliers $26.00-$4800.00

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