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Clinical ophthalmology

IF: 1.8
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Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections.

Published:1 March 2008 DOI: 10.2147/opth.s1666 PMID: 19668391
Darlene Miller

Abstract

Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox((R))) is the ocular formulation/adaptation of moxifloxacin. Moxifloxacin is a broad spectrum 8-methoxyfluoroquinolone which terminates bacterial growth by binding to DNA gyrase (topoisomerase II) and topoisomerase IV, essential bacterial enzymes involved in the replication, translation, repair and recombination of deoxyribonucleic acid. Affinity for both enzymes improves potency and reduces the probability of selecting resistant bacterial subpopulations. Vigamox is a bactericidal, concentration dependent, anti-infective. It is preservative free, and well tolerated with minimal ocular side effects. It provides increased penetration into ocular tissues and fluids with improved activity against Streptococci and Staphylococci species and moderate to excellent activity against clinically relevant, gram-negative ocular pathogens.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Moxifloxacin hydrochloride 186826-86-8 C21H25ClFN3O4 761 suppliers $5.00-$2000.00
DNA GYRASE 5 suppliers $345.00-$879.00
Topoisomerase IV inhibitor 1 2883403-42-5 3 suppliers Inquiry

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