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Mini reviews in medicinal chemistry

Mini reviews in medicinal chemistry

IF: 3.29
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7-Azaindole Analogues as Bioactive Agents and Recent Results.

Published:1 January 2019 DOI: 10.2174/1389557518666180928154004 PMID: 30264679
Neha Sharma, Anurag

Abstract

Azaindoles have been accepted as important structures having various biological activities in medicinal chemistry in novel drug discovery. Various azaindole derivatives have been used commercially and newer analogues are synthesized continuously. As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonists, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthma and chemokine receptor- 2 (CCR2) antagonists. This review consists of biological activities of various azaindole analogs, reported so far, and their structure activity relations, along with future perspectives in this field.

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