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BMJ Case Reports

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Fluorescence in a cryptococcoma following administration of 5-aminolevulinic acid hydrochloride (Gliolan).

Published:11 April 2017 DOI: 10.1136/bcr-2017-219469 PMID: 28400397
Waldo Gerard Solis, Mitchell Hansen

Abstract

A 54-year-old man presented with two episodes of dysarthria and left facial droop. Both episodes resolved by the time of examination. MRI of the brain revealed a right frontotemporal, heterogeneously enhancing mass with surrounding vasogenic oedema, suggestive of a high-grade primary brain neoplasm. The patient was administered preoperative 5-aminolevulinic acid hydrochloride (Gliolan), and fluorescence-guided resection of the lesion was undertaken. Cryptococcus gattii infection was diagnosed from the specimen and the patient was given appropriate antifungal treatment. This is the first reported case of Gliolan-mediated fluorescence in a fungal abscess and highlights one of the potential pitfalls in fluorescence-guided surgery.

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5-Aminolevulinic acid hydrochloride 5451-09-2 C5H10ClNO3 604 suppliers $16.80-$1760.00
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