天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Food Science & Nutrition >>article
Food Science & Nutrition

Food Science & Nutrition

IF: 3.5
Download PDF

Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential

Published:15 June 2016 DOI: 10.1002/fsn3.392 PMID: 28265364
Earle R. Nestmann

Abstract

Palmitoylethanolamide (PEA) is a natural fatty acid amide found in a variety of foods, which was initially identified in egg yolk. MicroPEA of defined particle size (0.5–10?μm) was evaluated for mutagenicity in Salmonella typhimurium, for clastogenicity/aneuploidy in cultured human lymphocytes, and for acute and subchronic rodent toxicity in the rat, following standard OECD test protocols, in accordance with Good Laboratory Practice (GLP). PEA did not induce mutations in the bacterial assay using strains TA1535, TA97a, TA98, TA100, and TA102, with or without metabolic activation, in either the plate incorporation or liquid preincubation methods. Similarly, PEA did not induce genotoxic effects in human cells treated for 3 or 24?h without metabolic activation, or for 3?h with metabolic activation. PEA was found to have an LD50 greater than the limit dose of 2000?mg/kg body weight (bw), using the OECD Acute Oral Up and Down Procedure. Doses for the 90-day rat oral toxicity study were based on results from the preliminary 14-day study, that is, 250, 500, and 1000?mg/kg bw/day. The No Effect Level (NOEL) in both subchronic studies was the highest dose tested.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Palmitoylethanolamide 544-31-0 C18H37NO2 353 suppliers $21.00-$891.38
SALMONELLA TYPHIMURIUM 10 suppliers Inquiry

Similar articles

IF:4.4

Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease

Frontiers in Pharmacology S. Beggiato,?M. C. Tomasini,etc Published: 24 July 2019
IF:8.5

Palmitoylethanolamide gels edible oils

Food Chemistry Duncan Schwaller, Yi Sui,etc Published: 30 August 2022
IF:0

Legal status and toxicity of saponins

Food and cosmetics toxicology A.J. George,etc Published: 1 January 1965