天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Drug and Chemical Toxicology >>article
Drug and Chemical Toxicology

Drug and Chemical Toxicology

IF: 2.1
Download PDF

Effects of a 28-day oral exposure to a 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one biocide formulation in Sprague-Dawley rats.

Published:1 April 2014 DOI: 10.3109/01480545.2013.834353 PMID: 24111717
Guillaume Pelletier, Victor E Valli, Marc Rigden, Raymond Poon

Abstract

Biocides are added to biodiesels to prevent degradation resulting from microbial growth. A 28-day repeated oral dose study was conducted to assess a potential risk arising from ingestion of isothiazolinone biocides in biodiesels. A mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (CMIT/MIT) diluted in corn oil was administered by gavage to male and female rats at 0, 0.26, 0.78, 2.33 and 7.0?mg/kg body weight per day. Rat water and food consumption was monitored. At the end of the dosing period, organs were weighed and histological examinations performed. Hematology, serum clinical chemistry and biomarkers of inflammation were assessed. Reduction of serum triglyceride levels in males and induction of hepatic phase 1 xenobiotic metabolizing enzymes in females accompanied by subtle histological changes in the liver were observed at the highest CMIT/MIT exposure. These changes were more indicative of an adaptive, reversible response than overt toxicity. Based on recommended levels for the control of microbial growth in fuels, CMIT/MIT contained in accidentally ingested biodiesels is not expected to represent a significant health risk.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
2-Methyl-4-isothiazolin-3-one 2682-20-4 C4H5NOS 487 suppliers $10.00-$615.00
Isothiazolinones 26172-55-4 C4H4ClNOS 432 suppliers $15.00-$4161.85
CORN OIL 8001-30-7 N/A 168 suppliers $60.00-$500.00

Similar articles

IF:0.9

Antifungal activities of bronopol and 2-methyl-4-isothiazolin-3-one (MT) against saprolegnia.

Biocontrol science Heisuke Oono, Kishio Hatai,etc Published: 1 December 2007
IF:4.3

Acute effects of exposure to vapors of 3-methyl-1-butanol in humans.

Indoor air L Ernstg?rd, D Norb?ck,etc Published: 1 June 2013