天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Pharmacology & Therapeutics >>article
Pharmacology & Therapeutics

Pharmacology & Therapeutics

IF: 12
Download PDF

Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy

Published:1 November 2019 DOI: 10.1016/j.pharmthera.2019.107396 PMID: 31356908
Jean-Fran?ois Goossens , Christian Bailly

Abstract

Ursodeoxycholic acid (UDCA) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. UDCA is also a long-established drug, largely used for the dissolution of cholesterol gallstones, the treatment of primary biliary cholangitis and other hepatobiliary disorders. The history of UDCA is briefly retraced here as well as its multifactorial mechanism of action, based on its anti-inflammatory, antioxidant and cytoprotective activities. The present review is centred around the anticancer properties of UDCA and synthetic antitumor derivatives designed over the past 20?years. Paradoxically, depending on the conditions, UDCA exhibits both pro- and anti-apoptotic properties toward different cell types. In particular, the UDCA drug can protect epithelial cells from damages and apoptosis while inducing inhibition of proliferation and apoptotic and/or autophagic death of cancer cells. The effects of UDCA on cancer cell migration, cancer stem cells and drug-induced dysbiosis are also evoked. The drug has revealed modest activities against colon and gastric cancers but may be useful to improve treatments of hepatocellular carcinoma, notably in combination with other drugs such as sorafenib. UDCA can also protect from damages induced by cancer chemotherapeutic agents. The potential of UDCA in cancer, as a chemo-protecting or chemotherapeutic agent, is highlighted here as well as the design of tumour-active derivatives, including UDCA-drug conjugates. A repurposing of UDCA in oncology should be further considered.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Ursodeoxycholic acid 128-13-2 C24H40O4 795 suppliers $30.00-$3418.80
Sorafenib 284461-73-0 C21H16ClF3N4O3 596 suppliers $11.00-$756.25

Similar articles

IF:2.9

Therapeutic role of ursodeoxycholic acid in colitis-associated cancer via gut microbiota modulation.

Neural Regeneration Research Qilang He,?Jinjie Wu,etc Published: 1 February 2023
IF:0

Exploring the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells

Neural Regeneration Research Weijian Meng, Sophia Xie,etc Published: 7 September 2024
IF:14.7

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

Neural Regeneration Research Yeuan Ting Lee, Yi Jer Tan,etc Published: 1 February 2023