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Molecular Cancer Therapeutics

Molecular Cancer Therapeutics

IF: 5.29
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Cellular and molecular pharmacology of oxaliplatin.

Published:1 January 2002 DOI: PMID: 12467217
Eric Raymond, Sandrine Faivre, Stephen Chaney, Jan Woynarowski, Esteban Cvitkovic

Abstract

Oxaliplatin, a diaminocyclohexane-containing platinum, has a spectrum of activity and mechanisms of action and resistance that appear to be different from those of other platinum-containing compounds, notably cisplatin. The first part of this review describes the differences between oxaliplatin and cisplatin in terms of their spectrum of activity and adduct formation and then goes on to discuss molecular and cellular experimental data that potentially explain them. Particular emphasis is placed on the differential role of DNA repair mechanisms. In addition, the anticancer effects of oxaliplatin are optimized when it is administered in combination with other anticancer agents, such as 5-fluorouracil, gemcitabine, cisplatin, or carboplatin; topoisomerase I inhibitors; and taxanes. In vitro and preclinical combination data that could optimize oxaliplatin-based chemotherapy are also reviewed.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
5-Fluorouracil 51-21-8 C4H3FN2O2 941 suppliers $5.00-$2492.67
Cisplatin 15663-27-1 Cl2H6N2Pt 764 suppliers $17.00-$6890.00
Carboplatin 41575-94-4 C6H12N2O4Pt 644 suppliers $33.00-$3650.00
Gemcitabine 95058-81-4 C9H11F2N3O4 584 suppliers $6.00-$6080.00
Oxaliplatin 63121-00-6 C8H12N2O4Pt 169 suppliers Inquiry
Taxanes 8 suppliers Inquiry
Topoisomerase I antibody 5 suppliers Inquiry

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