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Hormone and Metabolic Research

Hormone and Metabolic Research

IF: 2
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Regulation of phosphatidylcholine biosynthesis by the methylation pathway in rat pituitary gland.

Published:1 August 1984 DOI: 10.1055/s-2007-1014809 PMID: 6469209
C Prasad, R M Edwards

Abstract

Rat pituitary extracts catalyze methylation of phosphatidylethanolamine to phosphatidylcholine using S-adenosyl-L-methionine as the methyl donor. In vitro incubation of hemipituitaries with 1 mM 2-methylaminoethanol led to a dose dependent decrease in phosphatidylethanolamine methyltransferase activity as well as the incorporation of the radioactivity from [3H-methyl]-L-methionine into phosphatidyl-choline. The inhibitory effect of 2-methylaminoethanol was selective for phospholipids methylation since protein carboxymethyltransferase and catechol-o-methyltransferase activities were not affected.

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Procduct Name CAS Molecular Formula Supplier Price
2-Methylaminoethanol 109-83-1 C3H9NO 498 suppliers $10.00-$1166.55
S-Adenosyl-L-methionine 29908-03-0 C15H22N6O5S 348 suppliers Inquiry
PHOSPHATIDYLETHANOLAMINE 90989-93-8 C9H18NO8P 88 suppliers $50.00-$1255.20
L-ALPHA-PHOSPHATIDYLCHOLINE, HEART, BOVINE 4 suppliers Inquiry

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