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Colloids and Surfaces B: Biointerfaces

Colloids and Surfaces B: Biointerfaces

IF: 5.4
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Fabrication of strontium carbonate-based composite bioceramics as potential bone regenerative biomaterials

Published:1 October 2022 DOI: 10.1016/j.colsurfb.2022.112755 PMID: 35973237
Changgui Huang , Jielin Zhou , Jin Rao , Xinyi Zhao , Xiumei Tian , Fupo He , Haishan Shi

Abstract

Strontium carbonate (SrC) bioceramics are proposed as potential biomaterials to efficaciously repair the bone defects. However, the development of SrC bioceramics is restricted by their intrinsic low mechanical strength. In this study, SrC-based composite bioceramics (SrC-SrP) were fabricated by incorporating strontium-containing phosphate glass (SrP). The results indicated that aside from the main crystalline phase SrC, new compounds were generated in the SrC-SrP bioceramics. Incorporating 10?wt% SrP promoted densification, thus dramatically improving compressive strength of SrC-SrP bioceramics. The SrC-SrP bioceramics facilitated apatite precipitation on their surface, and sustainedly released strontium, phosphorus and sodium ions. Compared with the well-known β-tricalcium phosphate bioceramics, the SrC-SrP bioceramics with certain amounts of SrP enhanced proliferation, alkaline phosphatase activity and osteogenesis-related gene expressions of mouse bone mesenchymal stem cells. The SrC-SrP bioceramics with appropriate constituent can serve as novel bone regenerative biomaterials.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Dimethyl succinate 106-65-0 C6H10O4 563 suppliers $6.00-$12579.90
Potassium phosphate tribasic 7778-53-2 K3PO4 529 suppliers $5.00-$1130.00
Calcium phosphate 7758-87-4 Ca3O8P2 472 suppliers $5.00-$1057.00
Strontium carbonate 1633-05-2 CO3Sr 463 suppliers $5.00-$8750.00
Phosphorus 7723-14-0 P 274 suppliers $46.30-$1445.60
STRONTIUM 7440-24-6 Sr 159 suppliers $32.65-$4040.00
STRESSCOPIN-RELATED PEPTIDE (HUMAN) 348626-74-4 C205H358N68O57 48 suppliers $685.00-$894.00
SRC 23 suppliers Inquiry
APATITE 64476-38-6 2 suppliers Inquiry

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