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ACS Applied Materials & Interfaces

ACS Applied Materials & Interfaces

IF: 8.3
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Iontophoresis-Integrated Smart Microneedle Delivery Platform for Efficient Transdermal Delivery and On-Demand Insulin Release

Published:12 December 2024 DOI: 10.1021/acsami.4c18381 PMID: 39668130
Mingwei Peng,?Ziwen Heng,?Dewei Ma,?Bo Hou,?Keke Yang,?Qinglong Liu,?Zhongwei Gu,?Wei Liu,?Siyuan Chen

Abstract

Transdermal insulin delivery in a painless, convenient, and on-demand way remains a long-standing challenge. A variety of smart microneedles (MNs) fabricated by glucose-responsive phenylboronic acid hydrogels have been previously developed to provide painless and autonomous insulin release in response to a glucose level change. However, like the majority of MNs, their transdermal delivery efficiency was still relatively low compared to that with subcutaneous injection. Herein, we report an iontophoresis (ITP)-integrated smart MNs delivery platform with enhanced transdermal delivery efficiency and delivery depth. Carbon nanotubes (CNTs) were induced in the boronate-containing hydrogel to develop a semi-interpenetrating network hydrogel with enhanced stiffness and conductivity. Remarkably, ITP not only facilitated efficient and deeper transdermal delivery of insulin via electroosmosis and electrophoresis but also well-maintained glucose responsiveness. This ITP-combined smart MNs delivery platform, which could provide on-demand insulin delivery in a painless, convenient, and safe way, is promising to achieve persistent glycemic control. Furthermore, transdermal delivery of payloads with a wide size range was achieved by this delivery platform and thus shed light on the development of an efficient transdermal delivery platform with deep skin penetration in a minimally invasive way.

Substances (11)

Materials
Procduct Name CAS Molecular Formula Supplier Price
D(+)-Glucose 50-99-7 C6H12O6 1113 suppliers $6.00-$26950.00
Methanol 67-56-1 CH4O 832 suppliers $9.00-$7620.00
Ammonium persulfate 7727-54-0 H8N2O8S2 682 suppliers $13.98-$3100.00
Hyaluronic acid 9004-61-9 C14H22NNaO11 612 suppliers $60.00-$1174.00
N,N,N',N'-Tetramethylethylenediamine 110-18-9 C6H16N2 605 suppliers $10.00-$2091.40
Rhodamine B 81-88-9 C28H31ClN2O3 551 suppliers $26.00-$957.10
Agarose 9012-36-6 C10H15N3O3 325 suppliers $25.50-$2810.00
Trypan Blue 72-57-1 C34H24N6Na4O14S4 309 suppliers $5.60-$1572.48
Fluorescein isothiocyanate 27072-45-3 C21H11NO5S 213 suppliers $42.90-$1250.00
INSULIN 11070-73-8 C254H377N65O75S6 193 suppliers $72.00-$2660.00