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Carbohydrate Polymers

Carbohydrate Polymers

IF: 10.69
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A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin

Published:15 November 2018 DOI: 10.1016/j.carbpol.2018.08.011 PMID: 30177174
So Hyun Park, Hyuk Soo Shin, Soo Nam Park

Abstract

In this study, a pH-responsive hydrogel (cl-CMC-g-pHEA), based on carboxymethyl cellulose/2-hydroxyethyl acrylate, was prepared. Its physicochemical properties and applicability as a transdermal delivery system for naringenin (NRG) were investigated. The hydrogel was synthesized via radical polymerization; its structure was analyzed by FT-IR and 1H NMR. The water loss amount was measured by using thermogravimetric analysis; a porous 3D network structure was confirmed by SEM. All hydrogels showed greater swelling ratio at pH 7.5 and 8.5 than at pH 5.5. Rheological and texture analyses indicated a stable gel network and that grafting and crosslinking density influenced the mechanical properties of the hydrogel. The release behavior of NRG from the hydrogel could be explained by the Fickian diffusion mechanism. The hydrogel system enhanced transdermal delivery of NRG. Therefore, this novel pH-responsive cl-CMC-g-pHEA hydrogel may be useful as a transdermal delivery system for NRG and has potential applications in the treatment of atopic dermatitis.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
2-Hydroxyethyl acrylate 818-61-1 C5H8O3 528 suppliers $6.00-$4068.72
Naringenin 480-41-1 C15H12O5 470 suppliers $5.00-$6000.00
Carboxymethyl cellulose 9000-11-7 C6H12O6 288 suppliers $40.00-$4847.97

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