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Separation and Purification Technology

Separation and Purification Technology

IF: 8.09
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Cyclodextrin metal–organic framework derived nano-cubic gel particles for the efficient removal of bilirubin

Published:13 December 2024 DOI: 10.1016/j.seppur.2024.131071
Jing Yang, Yong Yuan, Jiongrui Hou, Zhiyong Xu, Yu Du, Jingqin Yang, Shaoyun Shan, Tianding Hu, Chengxiao Wang, Hongying Su

Abstract

Hemoperfusion adsorption has been extensively studied for the removal of bilirubin from the blood of patients suffering from acute liver failure, and development of high performance adsorbents is significant to enhance its therapeutic efficacy. In this study, cubic gel nanoparticles (CGNPs) with ordered framework of cyclodextrin (CD) molecules and similar porous structure to metal–organic frameworks (MOFs) was successfully prepared and evaluated as adsorbent to remove bilirubin in blood. Accordingly, γ-CD-MOF with particle size between 300–500?nm was prepared by vapor diffusion method. By further covalently cross-linking of CD molecules and removing of metal ions (K+), CD-MOF derivative CGNPs with excellent water stability were obtained. Due to the host–guest interaction between CD and bilirubin molecules, the porous structure and spherical cavity of CD-MOF, CGNPs could rapidly adsorb bilirubin within 15?min, achieving a bilirubin removal rate of over 95?%. A high adsorption capacity of 732.11?mg·g?1 was obtained at equilibrium within 2?h. Moreover, the CGNPs showed good blood compatibility through hemolysis and coagulation tests, and a reasonable bilirubin removal rate at 53.4?% was achieved in simulated hyperbilirubinemia plasma. The above results indicate that cubic gel particles with ordered CD frameworks analogous to MOF structures are promising adsorbent for effective removal of bilirubin in hemoperfusion.

Substances (10)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dimethyl sulfoxide 67-68-5 C2H6OS 1348 suppliers $15.00-$120900.00
Sodium hydroxide 1310-73-2 NaOH 1212 suppliers $14.00-$16472.00
Hexadecyl trimethyl ammonium bromide 57-09-0 C19H42BrN 847 suppliers $6.00-$19422.00
Methanol 67-56-1 CH4O 838 suppliers $9.00-$7620.00
Ethanol 64-17-5 C2H6O 809 suppliers $10.00-$17310.00
Potassium hydroxide 1310-58-3 KOH 748 suppliers $10.00-$7430.00
Sodium Phosphate, Dibasic 7558-79-4 Na2HPO4 662 suppliers $9.00-$4630.00
Bilirubin 635-65-4 C33H36N4O6 589 suppliers $30.00-$2637.00
gamma-Cyclodextrin 17465-86-0 C48H80O40 436 suppliers $6.00-$12760.00
Ethylene glycol diglycidyl ether 2224-15-9 C8H14O4 291 suppliers $23.00-$398.00

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