天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Cell >>article
Cell

Cell

IF: 45.5
Download PDF

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration

Published:13 December 2024 DOI: 10.1016/j.cell.2024.11.004
Han Chen, Chao Liu, Shiyao Cui, Yingqian Xia, Ke Zhang, Hanxiao Cheng, Jingyu Peng, Xiaoling Yu, Luyang Li, Hualin Yu, Jufang Zhang, Ju-Sheng Zheng, Bing Zhang

Abstract

Intermittent fasting has gained global popularity for its potential health benefits, although its impact on somatic stem cells and tissue biology remains elusive. Here, we report that commonly used intermittent fasting regimens inhibit hair follicle regeneration by selectively inducing apoptosis in activated hair follicle stem cells (HFSCs). This effect is independent of calorie reduction, circadian rhythm alterations, or the mTORC1 cellular nutrient-sensing mechanism. Instead, fasting activates crosstalk between adrenal glands and dermal adipocytes in the skin, triggering the rapid release of free fatty acids into the niche, which in turn disrupts the normal metabolism of HFSCs and elevates their cellular reactive oxygen species levels, causing oxidative damage and apoptosis. A randomized clinical trial (NCT05800730) indicates that intermittent fasting inhibits human hair growth. Our study uncovers an inhibitory effect of intermittent fasting on tissue regeneration and identifies interorgan communication that eliminates activated HFSCs and halts tissue regeneration during periods of unstable nutrient supply.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Glycerol 56-81-5 C3H8O3 1785 suppliers $5.00-$6250.00
L-Glutamine 56-85-9 C5H10N2O3 1143 suppliers $5.00-$10696.00
Hydrocortisone 50-23-7 C21H30O5 844 suppliers $25.00-$2600.00
Paraformaldehyde 30525-89-4 (CH2O)x 736 suppliers $18.00-$1190.00
Palmitic acid 57-10-3 C16H32O2 668 suppliers $5.00-$1166.55
Glutaraldehyde 111-30-8 C5H8O2 561 suppliers $13.50-$1930.00
Propranolol hydrochloride 318-98-9 C16H22ClNO2 494 suppliers $10.00-$3326.40
Deoxyribonuclease 9003-98-9 NULL 290 suppliers $58.00-$2170.00
INSULIN 11070-73-8 C254H377N65O75S6 194 suppliers $72.00-$2660.00
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE 555-60-2 C9H5ClN4 146 suppliers $25.40-$800.00

Similar articles

IF:27.4

Additively Manufactured Biodegradable Zn‐Based Porous Scaffolds to Suppress Osteosarcoma and Promote Osteogenesis

Advanced Materials Yupu Lu, Aobo Liu,etc Published: 20 November 2024
IF:11

Minoxidil: mechanisms of action on hair growth

British Journal of Dermatology A.G. Messenger, J. Rundegren,etc Published: 19 February 2004
IF:2.7

Penetration of different molecular weight hydrolysed keratins into hair fibres and their effects on the physical properties of textured hair

International Journal of Cosmetic Science E. Malinauskyte, R. Shrestha,etc Published: 18 September 2020