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Chemical Engineering Journal

Chemical Engineering Journal

IF: 13.3
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Injectable biomimetic microcarriers harness synergistic effects of paracrine factors and cellular membranes to alleviate osteoarthritis

Published:9 December 2024 DOI: 10.1016/j.cej.2024.158451
Manyu Chen, Jing Wang, Yuhan Liu, Xiaolin Cui, Jie Liang, Ning Lei, Yumei Xiao, Qiguang Wang, Yujiang Fan, Xingdong Zhang

Abstract

Osteoarthritis (OA), characterized by cartilage degeneration and functional impairment, remains a significant unmet medical need with limited therapeutic options available. While stem cell therapies, particularly those derived from bone marrow mesenchymal stem cells (BMSCs), hold great promise, they are hampered by challenges including cell instability and safety concerns. This study develops and investigates the potential of biomimetic microcarriers (BMSCs-CF@M-PLGA), synthetic cells that encapsulate BMSC paracrine factors within PLGA microspheres and are coated with BMSC membranes. These cells aim to overcome the limitations of conventional stem cell therapies while maintaining their therapeutic efficacy. In vitro experiments demonstrated that BMSCs-CF@M-PLGA significantly enhance chondrocyte proliferation, migration, and extracellular matrix synthesis, attributed to the synergistic action of paracrine factors and the protective properties of the cell membranes. In vivo studies confirmed the therapeutic efficacy of BMSCs-CF@M-PLGA in OA rat models, resulting in improved joint morphology and cartilage structure. Transcriptomic analysis revealed the regulation of extracellular matrix synthesis, cell survival, and inflammation pathways, with a shift towards reduced pro-inflammatory cytokines and increased anti-inflammatory cytokines. This study highlights the encouraging therapeutic potential of BMSCs-CF@M-PLGA, offering enhanced stability, safety, and convenience for OA treatment.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dichloromethane 75-09-2 CH2Cl2 1290 suppliers $8660.00
Poly(vinyl alcohol) 9002-89-5 C2H4O 602 suppliers $4353.77
Rhodamine B 81-88-9 C28H31ClN2O3 556 suppliers $26.00-$957.10

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