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PLoS ONE

PLoS ONE

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Enhanced bacteriostasis and osseointegrative properties of SiRNA-modified polyetheretherketone surface for implant applications

Published:5 December 2024 DOI: 10.1371/journal.pone.0314091 PMID: 39636795
Zhen Liu,?Libin Yang,?Yazhuo Ni,?Keying Chen,?Qiquan Yan,?Zhiying Zhao,?Bo Xu,?Yaoyang Li,?Rui Li,?Jianwen Li

Abstract

Polyetheretherketone (PEEK), bearing an elastic modulus that effectively simulates the innate properties of natural bone, has come into the spotlight as a promising bone substitute material. Nonetheless, the biologically inert nature of PEEK, combined with its insubstantial osseointegration and sterilization capabilities, pose constraints on its clinical application in the realm of implants. RNA interference (RNAi), an effective technique used for gene expression regulation, has begun to be applied in implant surface modification. Herein, siCKIP-1 is securely affixed to the surface of PEEK implants, aided by an antibacterial polyphenol tannic acid (pTAN) coatings, enhancing physiologic osseointegration and inhibiting bacterial infection. This method breakthrough not merely facilitates the convenience, but also multifaceted PEEK implants' refinements. The modified PEEK implants have impressive biocompatibility coupled with a noteworthy degree of antibacterial properties. Meanwhile, modified PEEK implants improved osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) and demonstrated excellent osteointegrative properties in rat femur implantation models. Therefore, identifying a new implant material with excellent biocompatibility and biomechanical properties is essential.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dexamethasone 50-02-2 C22H29FO5 786 suppliers $20.00-$5210.50
Paraformaldehyde 30525-89-4 (CH2O)x 736 suppliers $18.00-$1190.00
Triton X-100 9002-93-1 (C2H4O)nC14H22O 535 suppliers $18.00-$610.00
Bovine albumin 9048-46-8 N/A 506 suppliers $15.00-$17060.00
Alizarin Red S 130-22-3 C14H7NaO7S 463 suppliers $10.00-$900.00
Trypsin 9002-07-7 C35H47N7O10 455 suppliers $17.70-$24930.00

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