天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Advanced Materials >>article
Advanced Materials

Advanced Materials

IF: 27.39
Download PDF

Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide‐Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy

Published:6 December 2024 DOI: 10.1002/adma.202413108
Yinli Jin, Shuhua Liu, Xueyang Wang, Chenyuan Wang, Qiongfang Ruan, Wei Li

Abstract

Chronic wounds impose significant physical and mental burdens on patients. Nano-based formulations offer a promising strategy for chronic wound healing due to their non-invasive nature and enhanced biofilms penetration, but they often lack targeting capability or fail to achieve long-term and synergistic effects. In this work, a multifunctional microneedle (MN) patch loaded with engineered nitric oxide (NO)-releasing nanocarriers are presented that encapsulate an antibacterial agent and are immobilized with Concanavalin A (Con A) and NO molecules for targeted and synergistic treatment of chronic wounds. With the assistance of MNs, the nanoparticles (NPs) can directly cross bacterial biofilms and be efficiently delivered to wound tissues, where they target harmful bacteria through the specific recognition between Con A and polysaccharides on bacterial surfaces, followed by the release of the encapsulated antimicrobial agent, thereby achieving effective antibacterial effect. Moreover, the NPs generate NO in a sustained manner as they dissociate in the wound tissue, which exerts potent anti-inflammatory action and benefits tissue regeneration, further promoting chronic wounds closure. Consequently, this work provides a novel MN patch loaded with engineered NPs designed for accelerating chronic wound healing through targeted and synergistic therapy.

Substances (9)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Calcium chloride 10043-52-4 CaCl2 942 suppliers $5.00-$26371.00
N-Hydroxysuccinimide 6066-82-6 C4H5NO3 885 suppliers $5.00-$3348.80
Sucrose 57-50-1 C12H22O11 664 suppliers $5.00-$8025.00
Sodium alginate 9005-38-3 C5H7O4COONa 656 suppliers $14.00-$775.00
DL-Tryptophan 54-12-6 C11H12N2O2 416 suppliers $6.00-$1380.00
D-Cysteine hydrochloride 32443-99-5 C3H7NO2S.ClH.H2O 380 suppliers $9.00-$890.40
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5 C8H17N3 343 suppliers $5.00-$1190.00
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00
- Inquiry

Similar articles

IF:3.9

Graphene Oxide Functionalized GelMA Platform Loaded With BFP‐1 for Osteogenic Differentiation of BMSCs

Journal of biomedical materials research. Part A Taowen Guo, Shifan Lin,etc Published: 29 November 2024
IF:7.7

Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer

International Journal of Biological Macromolecules Mengke Lu, Jianxia Ding,etc Published: 1 December 2024