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Journal of Biochemical and Molecular Toxicology

Journal of Biochemical and Molecular Toxicology

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PKN2 Promotes Peripheral Nerve Repair by Regulating Autophagy via Activation of the AKT‐mTOR Pathway: An In Vitro Study

Published:22 November 2024 DOI: 10.1002/jbt.70063 PMID: 39575558
Lin Wang, Yuan‐sheng Huang

Abstract

This study aims to explore the role of Protein Kinase N2 (PKN2) in peripheral nerve injury (PNI) and evaluate its potential as a therapeutic target. The study employed a PC12 cell model to assess the effects of PKN2 overexpression on cell proliferation, migration, synaptic growth, and autophagic activity, with a focus on the regulatory role of the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. The results demonstrated that PKN2 overexpression significantly promoted PC12 cell proliferation and cell migration, while also enhancing synaptic growth. Additionally, a significant suppression of autophagy was observed. Mechanistic analysis revealed that PKN2 inhibited autophagic activity through the activation of the AKT/mTOR pathway. In summary, PKN2 plays a significant role in peripheral nerve repair by promoting cell proliferation, migration, and synaptic growth, while inhibiting autophagy through the AKT/mTOR pathway. These findings suggest that targeting PKN2 may represent an effective therapeutic strategy for the treatment of PNI.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 296 suppliers $14.10-$4800.00
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00
DAPI 47165-04-8 C16H15N5 13 suppliers $504.53-$504.53