天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> ACS Applied Nano Materials >>article
ACS Applied Nano Materials

ACS Applied Nano Materials

IF: 5.29
Download PDF

The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism

Published:17 May 2024 DOI: 10.3390/antiox13050613
Yanli Zhang, Jianfeng Huang, Yaru Zhang, Fengjuan Jiang, Shengpeng Li, Shuai He, Jiaojiao Sun, Dan Chen, Ying Tong, Qingfeng Pang, Yaxian Wu

Abstract

Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack of effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against various diseases by mitigating mitochondrial injury. C57BL/6 mice were exposed to 20 Gy of lung irradiation (IR) and received daily intraperitoneal injections of MOTS-c for 2 weeks. MOTS-c significantly ameliorated lung tissue damage, inflammation, and oxidative stress caused by radiation. Meanwhile, MOTS-c reversed the apoptosis and mitochondrial damage of alveolar epithelial cells in RP mice. Furthermore, MOTS-c significantly inhibited oxidative stress and mitochondrial damage in MLE-12 cells and primary mouse lung epithelial cells. Mechanistically, MOTS-c increased the nuclear factor erythroid 2-related factor (Nrf2) level and promoted its nuclear translocation. Notably, Nrf2 deficiency abolished the protective function of MOTS-c in mice with RP. In conclusion, MOTS-c alleviates RP by protecting mitochondrial function through an Nrf2-dependent mechanism, indicating that MOTS-c may be a novel potential protective agent against RP.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
MOTS-c 1627580-64-6 C101H152N28O22S2 123 suppliers Inquiry
NF-E2-related factor 2 33 suppliers Inquiry

Similar articles

IF:0

Gestational diabetes mellitus is associated with a low serum level of mitochondrial-derived peptide-MOTS-C

Turk biyokimya dergisi = Turkish journal of biochemistry Serdar ?zer, Filiz Alkan Baylan,etc Published: 21 September 2023
IF:6.2

1727-P: Mitochondrial-Encoded Peptide MOTS-c Prevents Senescence-Induced Diabetes

Diabetes B. Kong,?Serin Hong,etc Published: 20 June 2023
IF:5.3

Etoposide induces cell death via mitochondrial-dependent actions of p53.

Cancer Cell International Sarwat Jamil, Irene Lam,etc Published: 7 August 2015